Recombinant Human GPS2 Protein, GST-tagged

• Cat.No.: GPS2-5296H
• Product Overview: Human GPS2 full-length ORF ( AAH13652.1, 1 a.a. - 327 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 61.71 kDa
• AA Sequence: MPALLERPKLSNAMARALHRHIMME RERKRQEEEEVDKMMEQKMKEEQER RKKKEMEERMSLEETKEQILKLEEK LLALQEEKHQLFLQLKKVLHEEEKR RRKEQSDLTTLTSAAYQQSLTVHTG THLLSMQGSPGGHNRPGTLMAADRA KQMFGPQVLTTRHYVGSAAAFAGTP EHGQFQGSPGGAYGTAQPPPHYGPT QPAYSPSQQLRAPSAFPAVQYLSQP QPQPYAVHGHFQPTQTGFLQPGGAL SLQKQMEHANQQTGFSDSSSLRPMH PQALHPAPGLLASPQLPVQMQPAGK SGFAATSQPGPRLPFIQHSQNPRFY HK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: GPS2 G protein pathway suppressor 2 [ Homo sapiens ]
• Official Symbol: GPS2
• Synonyms: GPS2; G protein pathway suppressor 2; GPS-2; AMF-1; MGC104294; MGC119287; MGC119288; MGC119289
• Gene ID: 2874
• mRNA Refseq: NM_004489
• Protein Refseq: NP_004480
• MIM: 601935
• UniProt ID: Q13227