Recombinant Human GRAP Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human GRAP Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : GRAP-2969H
Product Overview : GRAP MS Standard C13 and N15-labeled recombinant protein (NP_006604) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 25.3 kDa
AA Sequence : MESVALYSFQ ATESDELAFN KGDTLKILNM EDDQNWYKAE LRGVEGFIPK NYIRVKPHPW YSGRISRQLA EEILMKRNHL GAFLIRESES SPGEFSVSVN YGDQVQHFKV LREASGKYFL WEEKFNSLNE LVDFYRTTTI AKKRQIFLRD EEPLLKSPGA CFAQAQFDFS AQDPSQLSFR RGDIIEVLER PDPHWWRGRS CGRVGFFPRS YVQPVHLTRT RPLEQKLISE EDLAANDILD YKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : GRAP GRB2-related adaptor protein [ Homo sapiens (human) ]
Official Symbol : GRAP
Synonyms : GRAP; GRB2-related adaptor protein; GRB2-related adapter protein; growth factor receptor-bound protein 2-related adaptor protein; MGC64880;
Gene ID : 10750
mRNA Refseq : NM_006613
Protein Refseq : NP_006604
MIM : 604330
UniProt ID : Q13588

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