| Description : |
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
119.9 kDa |
| AA Sequence : |
MTACARRAGGLPDPGLCGPAWWAPS LPRLPRALPRLPLLLLLLLLQPPAL SAVFTVGVLGPWACDPIFSRARPDL AARLAAARLNRDPGLAGGPRFEVAL LPEPCRTPGSLGAVSSALARVSGLV GPVNPAACRPAELLAEEAGIALVPW GCPWTQAEGTTAPAVTPAADALYAL LRAFGWARVALVTAPQDLWVEAGRS LSTALRARGLPVASVTSMEPLDLSG AREALRKVRDGPRVTAVIMVMHSVL LGGEEQRYLLEAAEELGLTDGSLVF LPFDTIHYALSPGPEALAALANSSQ LRRAHDAVLTLTRHCPSEGSVLDSL RRAQERRELPSDLNLQQVSPLFGTI YDAVFLLARGVAEARAAAGGRWVSG AAVARHIRDAQVPGFCGDLGGDEEP PFVLLDTDAAGDRLFATYMLDPARG SFLSAGTRMHFPRGGSAPGPDPSCW FDPNNICGGGLEPGLVFLGFLLVVG MGLAGAFLAHYVRHRLLHMQMVSGP NKIILTVDDITFLHPHGGTSRKVAQ GSRSSLGARSMSDIRSGPSQHLDSP NIGVYEGDRVWLKKFPGDQHIAIRP ATKTAFSKLQELRHENVALYLGLFL ARGAEGPAALWEGNLAVVSEHCTRG SLQDLLAQREIKLDWMFKSSLLLDL IKGIRYLHHRGVAHGRLKSRNCIVD GRFVLKITDHGHGRLLEAQKVLPEP PRAEDQLWTAPELLRDPALERRGTL AGDVFSLAIIMQEVVCRSAPYAMLE LTPEEVVQRVRSPPPLCRPLVSMDQ APVECILLMKQCWAEQPELRPSMDH TFDLFKNINKGRKTNIIDSMLRMLE QYSSNLEDLIRERTEELELEKQKTD RLLTQMLPPSVAEALKTGTPVEPEY FEQVTLYFSDIVGFTTISAMSEPIE VVDLLNDLYTLFDAIIGSHDVYKVE TIGDAYMVASGLPQRNGQRHAAEIA NMSLDILSAVGTFRMRHMPEVPVRI RIGLHSGPCVAGVVGLTMPRYCLFG DTVNTASRMESTGLPYRIHVNLSTV GILRALDSGYQVELRGRTELKGKGA EDTFWLVGRRGFNKPIPKPPDLQPG SSNHGISLQEIPPERRRKLEKARPG QFSTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
