Recombinant Human HDAC11 protein, His-tagged

• Cat.No.: HDAC11-92H
• Product Overview: Recombinant Human HDAC11(1-347 aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Description: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: Solution of purified recombinant protein in 50 mM Tris-HCl pH 7.5, 500 mM NaCl, 10% glycerol (w/v), 1 mM TCEP
• Molecular Mass: 42.1 kDa
• Storage: Store at -70 centigrade. Thaw quickly and store on ice before use. The remaining, unused, undiluted protein should be snap frozen, for example in a dry/ice ethanol bath or liquid nitrogen. Minimize freeze/thaws if possible, but very low volume aliquots (<5 µl) or storage of diluted protein is not recommended.

Gene Information

• Gene Name: HDAC11 histone deacetylase 11 [ Homo sapiens ]
• Official Symbol: HDAC11
• Synonyms: HDAC11; histone deacetylase 11; HD11; FLJ22237
• Gene ID: 79885
• mRNA Refseq: NM_024827
• Protein Refseq: NP_079103
• MIM: 607226
• UniProt ID: Q96DB2
• Chromosome Location: 3p25.1
• Pathway: NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding