| Description : |
This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
74 kDa |
| AA Sequence : |
MPHAFKPGDLVFAKMKGYPHWPARI DDIADGAVKPPPNKYPIFFFGTHET AFLGPKDLFPYDKCKDKYGKPNKRK GFNEGLWEIQNNPHASYSAPPPVSS SDSEAPEANPADGSDADEDDEDRGV MAVTAVTATAASDRMESDSDSDKSS DNSGLKRKTPALKMSVSKRARKASS DLDQASVSPSEEENSESSSESEKTS DQDFTPEKKAAVRAPRRGPLGGRKK KKAPSASDSDSKADSDGAKPEPVAM ARSASSSSSSSSSSDSDVSVKKPPR GRKPAEKPLPKPRGRKPKPERPPSS SSSDSDSDEVDRISEWKRRDEARRR ELEARRRREQEEELRRLREQEKEEK ERRRERADRGEAERGSGGSSGDELR EDDEPVKKRGRKGRGRGPPSSSDSE PEAELEREAKKSAKKPQSSSTEPAR KPGQKEKRVRPEEKQQAKPVKVERT RKRSEGFSMDRKVEKKKEPSVEEKL QKLHSEIKFALKVDSPDVKRCLNAL EELGTLQVTSQILQKNTDVVATLKK IRRYKANKDVMEKAAEVYTRLKSRV LGPKIEAVQKVNKAGMEKEKAEEKL AGEELAGEEAPQEKAEDKPSTDLSA PVNGEATSQKGESAEDKEHEEGRDS EEGPRCGSSEDLHDVREGPDLDRPG SDRQERERARGDSEALDEESTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
