Recombinant Human Hematopoietic Prostaglandin D Synthase, His-tagged

• Cat.No.: HPGDS-2402H
• Product Overview: Recombinant humanHPGDS protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: HPGDS, also known asGSTS, is a sigma class glutathione-S-transferase family member. The enzymecatalyzes the conversion of PGH2 to PGD2 and plays a role in the productionof prostanoids in the immune system and mast cells. The presence of thisenzyme can be used to identify the differentiation stage of humanmegakaryocytes
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 10% glycerol 0.15M NaCl,1mM DTT
• Molecular Weight: 25.9 kDa (223aa),confirmed by MALDI-TOF
• Purity: > 95% by SDS -PAGE
• Concentration: 1 mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMPNYKL TYFNMRGRAE IIRYIFAYLD IQYEDHRIEQ ADWPEIKSTL PFGKIPILEVDGLTLHQSLAIARYLTKNTD LAGNTEMEQC HVDAIVDTLD DFMSCFPWAE KKQDVKEQMF NELLTYNAPHLMQDLDTYLG GREWLIGNSV TWADFYWEIC STTLLVFKPD LLDNHPRLVT LRKKVQAIPA VANWIKRRPQTKL
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles

Gene Information

• Gene Name: HPGDShematopoietic prostaglandin D synthase [ Homo sapiens ]
• Official Symbol: HPGDS
• Synonyms: HPGDS; hematopoietic prostaglandinD synthase; glutathione S transferase sigma; GSTS; H PGDS; PGDS
• Gene ID: 27306
• mRNA Refseq: NM_014485
• Protein Refseq: NP_055300
• MIM: 602598
• Uniprot ID: O60760
• Chromosome Location: 4q22.2
• Pathway: Arachidonic acid metabolism,organism-specific biosystem; Arachidonic acid metabolism, conservedbiosystem; Metabolic pathways, organism-specific biosystem
• Function: calcium ion binding; glutathionetransferase activity; isomerase activity; magnesium ion binding;prostaglandin-D synthase activity