Recombinant Human HERC4, GST-tagged

• Cat.No.: HERC4-13739H
• Product Overview: Recombinant Human HERC4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 723-1049a.a.
• Description: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Homo sapiens ]
• Official Symbol: HERC4
• Synonyms: HERC4; HECT and RLD domain containing E3 ubiquitin protein ligase 4; hect domain and RLD 4; probable E3 ubiquitin-protein ligase HERC4; DKFZP564G092; KIAA1593; HECT domain and RCC1-like domain-containing protein 4; DKFZp564G092
• Gene ID: 26091
• mRNA Refseq: NM_015601
• Protein Refseq: NP_056416
• MIM: 609248
• UniProt ID: Q5GLZ8
• Chromosome Location: 10
• Pathway: Ubiquitin mediated proteolysis, organism-specific biosystem; Ubiquitin mediated proteolysis, conserved biosystem
• Function: acid-amino acid ligase activity; ligase activity; ubiquitin-protein ligase activity