Recombinant Human Herpesvirus 1 US12 Protein (1-88 aa), His-tagged

• Cat.No.: US12-2571H
• Product Overview: Recombinant Human Herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) US12 Protein (1-88 aa) is produced by E. coli expression system. This protein is fused with a 10xHis tag at the N-terminal. Protein Description: Full Length.

Specification

• Species: Human Herpesvirus 1
• Source: E.coli
• Tag: His
• Protein Length: 1-88 aa
• Description: Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. pty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 13.3 kDa
• AA Sequence: MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR
• Purity: > 85% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: US12 TAP transporter inhibitor ICP47 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]
• Official Symbol: US12
• Synonyms: US12
• Gene ID: 2703441
• Protein Refseq: YP_009137148
• UniProt ID: P03170