Recombinant Human HIPK3 Protein (P161-N562), GST tagged

• Cat.No.: HIPK3-1129H
• Product Overview: Recombinant Human GST-TEV-GG-HIPK3(P161-N562) Protein was expressed in Insect cell.

Specification

• Description: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: P161-N562
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: HIPK3 homeodomain interacting protein kinase 3 [ Homo sapiens (human) ]
• Official Symbol: HIPK3
• Synonyms: HIPK3; homeodomain interacting protein kinase 3; homeodomain-interacting protein kinase 3; DYRK6; FIST3; PKY; YAK1; ANPK; FIST; homolog of protein kinase YAK1; fas-interacting serine/threonine-protein kinase; androgen receptor-interacting nuclear protein kinase
• Gene ID: 10114
• mRNA Refseq: NM_001048200
• Protein Refseq: NP_001041665
• MIM: 604424
• UniProt ID: Q9H422