Recombinant Human HR Protein, MYC/DDK-tagged

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Recombinant Human HR Protein, MYC/DDK-tagged

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Cat.No. : HR-1887H
Product Overview : Recombinant human HR protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
Description : This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 127.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : HR hairless homolog (mouse) [ Homo sapiens ]
Official Symbol : HR
Synonyms : ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1
Gene ID : 3264
mRNA Refseq : NM_005144.4
Protein Refseq : NP_005135
MIM : 602302
UniProt ID : O43593

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