Recombinant Human HSPA4 Protein HSPA4-012H

Recombinant Human HSPA4 Protein

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Recombinant Human HSPA4 Protein

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Cat.No. : HSPA4-012H
Product Overview : Recombinant Human HSPA4 protein (2-641) without tag was espressed in insect cell.
Description : HSPA4 heat shock protein family A (Hsp70) member 4 are abundant and stress-inducible 70 kDa molecular chaperone proteinsencoded by a highly conserved, multigene family. They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly conserved EEVD motif at its C-terminus. Hsp70s are found in the cytosol, nuclei, endoplasmic reticulum, mitochondria, and chloroplasts of eukaryotes, as well as in bacteria. They function as molecular chaperones that assist in a wide range of cellular processes, including refolding of aggregated or misfolded proteins, co- and post-translational folding and assembly of nascent peptides, membrane translocation of secretory and organellar proteins, controlling activity of regulatory nuclear receptors, kinases and transcription factors, as well as acting cooperatively with the Hsp90 chaperone system in eukaryotes. The HSPA4 chaperone cycle is ATP-dependent and initiated by transient interaction of the HSPA4 substrate binding domain with hydrophobic regions within a peptide or protein. It consists of an alteration between the low-affinity ATP-bound state with fast rates of substrate exchange and the high-affinity ADP bound state with slow rates of substrate exchange. HSPA4 are subject to a variety of post-translational modifications and their expression is upregulated under conditions of cellular stress and in a variety of disease states.
Source : Insect cell
Species : Human
Form : 50 mM HEPES, pH 8.0, 150 mM sodium chloride, 1 mM DTT, and 10% glycerol
Bio-activity : ATPase activity confirmed by ADP detection assay
Molecular Mass : 71.7 kDa
Protein length : 2-641
Purity : ≥75% estimated by SDS-PAGE
Stability : ≥ 1 year
Storage : Store at -80 centigrade
SDS-PAGE analysis of HSPA4. :

Lane 1: MW Markers
Lane 2: HSPA4 BV (1 µg)
Lane 3: HSPA4 BV (2 µg)
Lane 4: HSPA4 BV (4 µg)

ATPase Activity of HSPA4 Expressed In Insect Cell. :

Gene Name : HSPA4 heat shock protein family A [ Homo sapiens (human) ]
Official Symbol : HSPA4
Synonyms : HSPA4; heat shock protein family A; RY; APG-2; HSPH2; hsp70; hsp70RY; HEL-S-5a; HS24/P52; heat shock 70 kDa protein 4; epididymis secretory sperm binding protein Li 5a; heat shock 70-related protein APG-2; heat shock 70kD protein 4; heat shock 70kDa protein 4; heat shock protein, 110 kDa; hsp70 RY
Gene ID : 3308
mRNA Refseq : NM_002154
Protein Refseq : NP_002145
MIM : 601113
UniProt ID : P34932

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