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Recombinant Human HSPA6 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : HSPA6-5652H
Product Overview : HSPA6 MS Standard C13 and N15-labeled recombinant protein (NP_002146) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 71 kDa
AA Sequence : MQAPRELAVGIDLGTTYSCVGVFQQ GRVEILANDQGNRTTPSYVAFTDTE RLVGDAAKSQAALNPHNTVFDAKRL IGRKFADTTVQSDMKHWPFRVVSEG GKPKVRVCYRGEDKTFYPEEISSMV LSKMKETAEAYLGQPVKHAVITVPA YFNDSQRQATKDAGAIAGLNVLRII NEPTAAAIAYGLDRRGAGERNVLIF DLGGGTFDVSVLSIDAGVFEVKATA GDTHLGGEDFDNRLVNHFMEEFRRK HGKDLSGNKRALRRLRTACERAKRT LSSSTQATLEIDSLFEGVDFYTSIT RARFEELCSDLFRSTLEPVEKALRD AKLDKAQIHDVVLVGGSTRIPKVQK LLQDFFNGKELNKSINPDEAVAYGA AVQAAVLMGDKCEKVQDLLLLDVAP LSLGLETAGGVMTTLIQRNATIPTK QTQTFTTYSDNQPGVFIQVYEGERA MTKDNNLLGRFELSGIPPAPRGVPQ IEVTFDIDANGILSVTATDRSTGKA NKITITNDKGRLSKEEVERMVHEAE QYKAEDEAQRDRVAAKNSLEAHVFH VKGSLQEESLRDKIPEEDRRKMQDK CREVLAWLEHNQLAEKEEYEHQKRE LEQICRPIFSRLYGGPGVPGGSSCG TQARQGDPSTGPIIEEVDTRTRPLE QKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : HSPA6 heat shock protein family A (Hsp70) member 6 [ Homo sapiens (human) ]
Official Symbol : HSPA6
Synonyms : HSPA6; heat shock 70kDa protein 6 (HSP70B); heat shock 70kD protein 6 (HSP70B); heat shock 70 kDa protein 6; heat shock 70 kDa protein B;
Gene ID : 3310
mRNA Refseq : NM_002155
Protein Refseq : NP_002146
MIM : 140555
UniProt ID : P17066

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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