Description : |
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. |
Source : |
E. coli |
Species : |
Human |
Tag : |
N-His |
Form : |
Solution |
Molecular Mass : |
100 kDa |
Protein Length : |
858 |
AA Sequence : |
MSVVGLDVGSQSCYIAVARAGGIET IANEFSDRCTPSVISFGSKNRTIGV AAKNQQITHANNTVSNFKRFHGRAF NDPFIQKEKENLSYDLVPLKNGGVG IKVMYMGEEHLFSVEQITAMLLTKL KETAENSLKKPVTDCVISVPSFFTD AERRSVLDAAQIVGLNCLRLMNDMT AVALNYGIYKQDLPSLDEKPRIVVF VDMGHSAFQVSACAFNKGKLKVLGT AFDPFLGGKNFDEKLVEHFCAEFKT KYKLDAKSKIRALLRLYQECEKLKK LMSSNSTDLPLNIECFMNDKDVSGK MNRSQFEELCAELLQKIEVPLYSLL EQTHLKVEDVSAVEIVGGATRIPAV KERIAKFFGKDISTTLNADEAVARG CALQCAILSPAFKVREFSVTDAVPF PISLIWNHDSEDTEGVHEVFSRNHA APFSKVLTFLRRGPFELEAFYSDPQ GVPYPEAKIGRFVVQNVSAQKDGEK SRVKVKVRVNTHGIFTISTASMVEK VPTEENEMSSEADMECLNQRPPENP DTDKNVQQDNSEAGTQPQVQTDAQQ TSQSPPSPELTSEENKIPDADKANE KKVDQPPEAKKPKIKVVNVELPIEA NLVWQLGKDLLNMYIETEGKMIMQD KLEKERNDAKNAVEEYVYEFRDKLC GPYEKFICEQDHQNFLRLLTETEDW LYEEGEDQAKQAYVDKLEELMKIGT PVKVRFQEAEERPKMFEELGQRLQH YAKIAADFRNKDEKYNHIDESEMKK VEKSVNEVMEWMNNVMNAQAKKSLD QDPVVRAQEIKTKIKELNNTCEPVV TQPKPKIESPKLERTPNGPNIDKKE EDLEDKNNFGAEPPHQNGECYPNEK NSVNMDLD |
Purity : |
> 90% |
Applications : |
WB; ELISA; FACS; FC |
Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : |
4°C |
Concentration : |
1 mg/mL |
Storage Buffer : |
Tris-HCl (pH 8). Sterile-filtered colorless solution. |
Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |