Recombinant Human HTR7, T7 -tagged

• Cat.No.: HTR7-26031TH
• Product Overview: Recombinant full length Human 5HT7 Receptor with proprietary tag; Predicted MWt 73.59 kDa.

Specification

• Description: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.
• Protein length: 432 amino acids
• Conjugation: T7
• Molecular Weight: 73.590kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
• Biological activity: useful for Antibody Production and Protein Array
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% GlutathioneNote: Glutathione is reduced
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MMDVNSSGRPDLYGHLRSFLLPEVG RGLPDLSPDGGADPVAGSWAPHLLS EVTASPAPTWDAPPDNASGCGEQIN YGRVEKVVIGSILTLITLLTIAGNC LVVISVCFVKKLRQPSNYLIVSLAL ADLSVAVAVMPFVSVTDLIGGKWIF GHFFCNVFIAMDVMCCTASIMTLCV ISIDRYLGITRPLTYPVRQNGKCMA KMILSVWLLSASITLPPLFGWAQNV NDDKVCLISQDFGYTIYSTAVAFYI PMSVMLFMYYQIYKAARKSAAKHKF PGFPRVEPDSVIALNGIVKLQKEVE ECANLSRLLKHERKNISIFKREQKA ATTLGIIVGAFTVCWLPFFLLSTAR PFICGTSCSCIPLWVERTFLWLGYA NSLINPFIYAFFNRDLRTTYRSLLQ CQYRNINRKLSAAGMHEALKLAERP ERPEFVL
• Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.

Gene Information

• Gene Name: HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) [ Homo sapiens ]
• Official Symbol: HTR7
• Synonyms: HTR7; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine receptor 7; 5 HT7
• Gene ID: 3363
• mRNA Refseq: NM_000872
• Protein Refseq: NP_000863
• MIM: 182137
• Uniprot ID: P34969
• Chromosome Location: 10q21-q24
• Pathway: Amine ligand-binding receptors, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem
• Function: G-protein coupled receptor activity; neurotransmitter receptor activity; receptor activity; serotonin receptor activity; signal transducer activity