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Recombinant Human IGFBP4 protein, T7/His-tagged

Cat.No. : IGFBP4-60H
Product Overview : Recombinant human IGFBP4 cDNA (22-258aa, derived from BC016041) fused with T7-His-TEV cleavage site Tag (29aa) at N-terminal was expressed in E. coli.
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  • Gene Information
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Source : E. coli
Species : Human
Tag : T7/His
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEFDEAIHCPPCSEEKLARCRPPV GCEELVREPGCGCCATCALGLGMPC GVYTPRCGSGLRCYPPRGVEKPLHT LMHGQGVCMELAEIEAIQESLQPSD KDEGDHPNNSFSPCSAHDRRCLQKH FAKIRDRSTSGGKMKVNGAPREDAR PVPQGSCQSELHRALERLAASQSRT HEDLYIIPIPNCDRNGNFHPKQCHP ALDGQRGKCWCVDRKTGVKLPGGLE PKGELDCHQLADSFRE
Purity : >90% by SDS-PAGE
Applications : 1. May be used for in vitro IGFBP4 mediated VEGF pathway regulation study on endothelial cell growth with this protein as either coating matrix protein or as soluble factor.
Storage : Keep at -80centigrade for long term storage. Product is stable at 4 centigrade for at least 30 days.
Gene Name : IGFBP4 insulin-like growth factor binding protein 4 [ Homo sapiens ]
Official Symbol : IGFBP4
Synonyms : IGFBP4; insulin-like growth factor binding protein 4; insulin like growth factor binding protein 4; insulin-like growth factor-binding protein 4; BP 4; HT29 IGFBP; IBP4; IGF binding protein 4; IGFBP 4; IBP-4; IGF-binding protein 4; BP-4; IGFBP-4; HT29-IGF
Gene ID : 3487
mRNA Refseq : NM_001552
Protein Refseq : NP_001543
MIM : 146733
UniProt ID : P22692
Chromosome Location : 17q12-q21.1
Pathway : Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem; Wnt signaling network, organism-specific biosystem;
Function : insulin-like growth factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does IGFBP4 play in bone growth and development, particularly in regulating osteoblast and osteoclast activity? 09/09/2022

IGFBP4 plays a key role in bone development, regulating bone-forming and bone-resorbing cells.

What is the impact of IGFBP4 on cardiovascular health, particularly in atherosclerosis and heart disease? 04/30/2022

IGFBP4 impacts cardiovascular health, influencing atherosclerosis and heart disease processes.

What are the effects of IGFBP4 dysregulation on aging and age-related diseases? 10/08/2019

Dysregulation of IGFBP4 is linked to aging and the progression of age-related diseases.

How does IGFBP4 contribute to metabolic regulation and insulin sensitivity? 11/25/2018

IGFBP4 is involved in metabolic regulation, affecting insulin sensitivity and glucose metabolism.

How does IGFBP4 modulate the activity of insulin-like growth factors (IGFs) in various tissues? 10/23/2018

IGFBP4 modulates IGF activity, affecting growth and metabolic functions in tissues.

How do alterations in IGFBP4 expression or function affect wound healing and tissue repair? 07/09/2018

Changes in IGFBP4 expression influence wound healing and tissue repair mechanisms.

How does IGFBP4 influence cancer progression, especially in hormone-dependent cancers? 05/26/2018

IGFBP4 influences cancer progression, particularly in cancers sensitive to hormonal changes.

Customer Reviews (3)

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Reviews
02/25/2019

    Accurate protein structural analysis, crucial for our investigations.

    10/23/2018

      Exceptional protein expression optimization support, greatly appreciated.

      06/06/2018

        Reliable mass spectrometry analysis, pivotal for proteomics studies.

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