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Active Recombinant Human IgG1Fc Protein, His-Avi-tagged, Biotinylated

Cat.No. : IgG1Fc-11H
Product Overview : Biotinylated Human IgG1 Fc, Avitag, His Tag is expressed from human HEK293 cells. It contains AA Pro 100 - Lys 330 (Accession # P01857-1 (C103S)).
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  • Gene Information
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Description : Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Measured by its binding ability in a functional ELISA against immobilized Recombinant Protein A (0.2 μg/well). The linear range is 0.8-12.5 ng/mL.
Molecular Mass : The protein has a calculated MW of 28.8 kDa. As a result of glycosylation, the protein migrates as 36 kDa under reducing (R) condition, and 60-66 kDa under non-reducing (NR) condition (SDS-PAGE).
Protein length : Pro 100 - Lys 330 (C103S)
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Homo sapiens (human) ]
Official Symbol : IgG1Fc
Synonyms : IgG1
Gene ID : 3500
MIM : 147100
UniProt ID : P01857

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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