Description : |
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
46.8 kDa |
AA Sequence : |
MEDIQTNAELKSTQEQSVPAESAAV LNDYSLTKSHEMENVDSGEGPANED EDIGDDSMKVKDEYSERDENVLKSE PMGNAEEPEIPYSYSREYNEYENIK LERHVVSFDSSRPTSGKMNCDVCGL SCISFNVLMVHKRSHTASAEARHIK AEMGSERALVLDRLASNVAKRKSSM PQKFIGEKRHCFDVNYNSSYMYEKE SELIQTRMMDQAINNAISYLGAEAL RPLVQTPPAPTSEMVPVISSMYPIA LTRAEMSNGAPQELEKKSIHLPEKS VPSERGLSPNNSGHDSTDTDSNHEE RQNHIYQQNHMVLSRARNGMPLLKE VPRSYELLKPPPICPRDSVKVINKE GEVMDVYRCDHCRVLFLDYVMFTIH MGCHGFRDPFECNMCGYRSHDRYEF SSHIARGEHRALLKTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |