Recombinant Human IL17A/IL17F protein
Cat.No. : | IL17AF-12H |
Product Overview : | A DNA sequence encoding the human IL17A ( NP_002181.1) (Met 1 - Ala 155) was expressed,constructed the plasmid 1;the human IL17F (NP_443104.1) (Met 1 - Gln 163) was expressed, constructed the plasmid 2. The two plasmids were co-expressed and the heterodimer was purified. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Predicted N Terminal : | Gly24 & Arg31 |
Form : | Lyophilized from sterile PBS, pH 7.4. |
Molecular Mass : | The recombinant heterodimer of human IL17A & IL17F comprises 265 (132+133) amino acids and has a calculated molecular mass of 30 (15.1+14.9) kDa. |
Purity : | > 95 % as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 centigrade |
Storage : | Store it under sterile conditions at -20 centigradeto -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL17F interleukin 17F [ Homo sapiens ] |
Official Symbol : | IL17F |
Synonyms : | IL17F; interleukin 17F; interleukin-17F; IL 17F; ML 1; ML1; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; ML-1; CANDF6; IL-17F; |
Gene ID : | 112744 |
mRNA Refseq : | NM_052872 |
Protein Refseq : | NP_443104 |
MIM : | 606496 |
UniProt ID : | Q96PD4 |
Chromosome Location : | 6p12 |
Pathway : | IL23-mediated signaling events, organism-specific biosystem; |
Function : | cytokine activity; cytokine binding; protein homodimerization activity; |
Products Types
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◆ Lysates | ||
IL17A-001HCL | Recombinant Human IL17A cell lysate | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAnimal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.
Inducing IL17A expression in T cells involves culturing them with specific cytokines.
Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.
Neutralizing antibodies block IL17A's effects in cell cultures or animal models.
Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.
IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.
Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.
Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.
Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.
Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.
Customer Reviews (3)
Write a reviewGood for receptor studies.
Effective in Th17 differentiation.
High bioactivity in various tissue types.
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