Recombinant Human IL1RAP Protein, Fc-tagged

• Cat.No.: IL1RAP-305H
• Product Overview: Recombinant human IL1RAP protein with Fc tag was expressed in HEK293.

Specification

• Description: This gene encodes a component of the interleukin 1 receptor complex, which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in membrane-bound and soluble isoforms differing in their C-terminus. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Molecular Mass: 65.7 kDa
• Protein length: 570
• AA Sequence: MTLLWCVVSLYFYGILQSDASERCD DWGLDTMRQIQVFEDEPARIKCPLF EHFLKFNYSTAHSAGLTLIWYWTRQ DRDLEEPINFRLPENRISKEKDVLW FRPTLLNDTGNYTCMLRNTTYCSKV AFPLEVVQKDSCFNSPMKLPVHKLY IEYGIQRITCPNVDGYFPSSVKPTI TWYMGCYKIQNFNNVIPEGMNLSFL IALISNNGNYTCVVTYPENGRTFHL TRTLTVKVVGSPKNAVPPVIHSPND HVVYEKEPGEELLIPCTVYFSFLMD SRNEVWWTIDGKKPDDITIDVTINE SISHSRTEDETRTQILSIKKVTSED LKRSYVCHARSAKGEVAKAAKVKQK VPAPRYTVELACGFGATVLLVVILI VVYHVYWLEMVLFYRAHFGTDETIL DGKEYDIYVSYARNAEEEEFVLLTL RGVLENEFGYKLCIFDRDSLPGGIV TDETLSFIQKSRRLLVVLSPNYVLQ GTQALLELKAGLENMASRGNINVIL VQYKAVKETKVKELKRAKTVLTVIK WKGEKSKYPQGRFWKQLQVAMPVKK SPRRSSSDEQGLSYSSLKNV
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: IL1RAP interleukin 1 receptor accessory protein [ Homo sapiens (human) ]
• Official Symbol: IL1RAP
• Synonyms: IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; C3orf13; IL 1RAcP; IL1R3; IL-1R3; interleukin-1 receptor 3; IL-1 receptor accessory protein; interleukin-1 receptor accessory protein beta; IL-1RAcP; FLJ37788
• Gene ID: 3556
• mRNA Refseq: NM_001167928
• Protein Refseq: NP_001161400
• MIM: 602626
• UniProt ID: Q9NPH3

Reviews

05/25/2021

High solubility.

07/22/2019

Good for intracellular staining.

05/13/2018

Effective in apoptosis assays.

Q&As

How can single-cell RNA sequencing and proteomics uncover IL1RAP's interactions with immune receptors within complex networks?

Single-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.

Can genome-wide mapping and functional assays reveal the epigenetic regulation and context-specific expression of the IL1RAP gene?

Genome mapping and assays unveil IL1RAP's epigenetic control.

How can we unravel IL1RAP's varied distribution across cell types and tissues, clarifying its functional versatility?

Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.

How do advanced imaging and genetic knockout models shed light on IL1RAP's role in immune cell dynamics and functions?

Advanced imaging and genetic models illuminate IL1RAP's immune role.

What insights do computational simulations and in vitro experiments provide into IL1RAP's interaction kinetics and stability?

Simulations and experiments reveal IL1RAP's interaction details.

Do engineered cellular models clarify IL1RAP's mechanisms in inflammasome activation and cytokine release?

Engineered cell models shed light on IL1RAP's role in inflammation.

Can structural biology techniques elucidate IL1RAP's conformational changes and ligand interactions in inflammation?

Structural techniques provide insights into IL1RAP's ligand interactions.

What strategies unveil the influence of post-translational modifications on IL1RAP's localization and signaling pathways?

Strategies uncover post-translational effects on IL1RAP's signaling.

How do organ-on-chip technologies mimic tissue microenvironments to explore IL1RAP's impact on signaling pathways?

Organ-on-chip tech explores IL1RAP's impact on pathways.

What innovative methods decode IL1RAP isoforms in different cells, revealing their impact on cellular responses?

Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.