Recombinant Human IL1RL2 protein, Fc-tagged

• Cat.No.: IL1RL2-337H
• Product Overview: Recombinant Human IL1RL2(Met1-Tyr337) fused with the Fc region of human IgG1 at the C-terminus was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
• Source: HEK293
• Species: Human
• Tag: Fc
• Predicted N Terminal: Asp 20
• Form: Lyophilized from sterile PBS, pH 7.4.1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Molecular Mass: The recombinant human IL1RL2 consists 559 amino acids and predicts a molecular mass of 63.2 kDa.
• Protein length: Met1-Tyr337
• Endotoxin: <1.0 eu per μg protein as determined by the lal>
• Purity: >90 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: IL1RL2 interleukin 1 receptor-like 2 [ Homo sapiens ]
• Official Symbol: IL1RL2
• Synonyms: IL1RL2; interleukin 1 receptor-like 2; interleukin-1 receptor-like 2; IL1R rp2; IL1RRP2; IL-1Rrp2; interleukin-1 receptor-related protein 2; IL1R-rp2
• Gene ID: 8808
• mRNA Refseq: NM_003854
• Protein Refseq: NP_003845
• MIM: 604512
• UniProt ID: Q9HB29
• Chromosome Location: 2q12
• Function: interleukin-1 receptor activity; interleukin-1, Type I, activating receptor activity; receptor activity; transmembrane signaling receptor activity

Reviews

11/17/2022

High purity.

03/07/2019

Good for receptor binding.

10/14/2018

Effective in inflammation assays.

Q&As

What is the role of Il1rl2 in cardiac hypertrophy?

Il1rl2 is involved in the development of cardiac hypertrophy.

How does Il1rl2 expression change in response to bacterial infection?

Il1rl2 expression is upregulated in response to bacterial infection.

How does Il1rl2 affect macrophage polarization?

Il1rl2 induces M2 macrophage polarization.

What is the affinity of Il1rl2 for its primary ligand?

Il1rl2 has high affinity for its primary ligand, IL-36.

What is the role of Il1rl2 in adipogenesis?

Il1rl2 promotes adipogenesis by activating PPAR-gamma.

What is the half-life of Il1rl2 in serum?

The half-life of Il1rl2 in serum is approximately 30 minutes.

Does Il1rl2 interact with any membrane receptors?

Il1rl2 interacts with IL-36R on the cell membrane.

Does Il1rl2 undergo post-translational modifications?

Il1rl2 undergoes phosphorylation.

Does Il1rl2 contribute to the blood-brain barrier permeability?

Il1rl2 increases blood-brain barrier permeability.

Is Il1rl2 expression influenced by circadian rhythms?

Il1rl2 expression is not influenced by circadian rhythms.