Recombinant Cynomolgus IL1RL2 protein, His-tagged

• Cat.No.: IL1RL2-0217C
• Product Overview: Recombinant Cynomolgus IL1RL2 protein(Asp20-Arg335), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Molecular Mass: This protein carries a polyhistidine tag at the C-terminus.The protein has a calculated MW of 37.9 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
• Proteinlength: Asp20-Arg335
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Official Symbol: IL1RL2

Gene Information

• Official Symbol: IL1RL2

Reviews

11/17/2022

High purity.

03/07/2019

Good for receptor binding.

10/14/2018

Effective in inflammation assays.

Q&As

What is the role of Il1rl2 in cardiac hypertrophy?

Il1rl2 is involved in the development of cardiac hypertrophy.

How does Il1rl2 expression change in response to bacterial infection?

Il1rl2 expression is upregulated in response to bacterial infection.

How does Il1rl2 affect macrophage polarization?

Il1rl2 induces M2 macrophage polarization.

What is the affinity of Il1rl2 for its primary ligand?

Il1rl2 has high affinity for its primary ligand, IL-36.

What is the role of Il1rl2 in adipogenesis?

Il1rl2 promotes adipogenesis by activating PPAR-gamma.

What is the half-life of Il1rl2 in serum?

The half-life of Il1rl2 in serum is approximately 30 minutes.

Does Il1rl2 interact with any membrane receptors?

Il1rl2 interacts with IL-36R on the cell membrane.

Does Il1rl2 undergo post-translational modifications?

Il1rl2 undergoes phosphorylation.

Does Il1rl2 contribute to the blood-brain barrier permeability?

Il1rl2 increases blood-brain barrier permeability.

Is Il1rl2 expression influenced by circadian rhythms?

Il1rl2 expression is not influenced by circadian rhythms.