Recombinant Human IL21 protein, Fc-tagged

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Recombinant Human IL21 protein, Fc-tagged

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Cat.No. : IL21-298H
Product Overview : Recombinant Human IL21 (Gln23-Ser155) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15/IL-21 family. Interleukin-21/IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21/IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Gln23
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 41.9 kDa. The protein migrates as 45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Gln23-Ser155
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of IL21-298H :

Human IL-21, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of IL21-298H :

Immobilized Human IL-21 R, His Tag at 2 μg/mL (100 μL/well) can bind Human IL-21, Fc Tag with a linear range of 0.2-8 ng/mL (QC tested).

Gene Name : IL21
Official Symbol : IL21
Synonyms : IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21
Gene ID : 59067
mRNA Refseq : NM_001207006
Protein Refseq : NP_001193935
MIM : 605384
UniProt ID : Q9HBE4

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