Recombinant Human IL22RA1 protein, His-Avi-tagged
|Product Overview :||Recombinant Human IL-22R alpha 1 Protein is expressed from mammalian with a His and Avi tag at the C-terminal. It contains Ala16-Thr228.|
- Gene Information
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|Description :||IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.|
|Form :||Supplied as 0.22um filtered solution in PBS (pH 7.4).|
|Molecular Mass :||The protein has a predicted MW of 27.3 kDa.Due to glycosylation, the protein migrates to 38-45KDa based on Bis-Tris PAGE result.|
|Protein length :||It contains Ala16-Thr228.|
|Endotoxin :||Less than 1EU per ug by the LAL method.|
|Purity :||> 95% as determined by Tris-Bis PAGE|
|Storage :||The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.|
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|Gene Name :||IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]|
|Official Symbol :||IL22RA1|
|Synonyms :||CRF2-9; CRF2-9interleukin 22 receptor; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; IL-22 R alpha 1; IL-22 receptor subunit alpha-1; IL22R alpha 1; IL22R; IL22R1; IL22RA1; IL-22Ra1; IL-22R-alpha-1; IL-TIF-R1; interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1; zcytoR11|
|Gene ID :||58985|
|mRNA Refseq :||NM_021258|
|Protein Refseq :||NP_067081|
|UniProt ID :||Q8N6P7|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
IL22RA1 undergoes phosphorylation.
IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.
IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.
IL22RA1 is involved in anti-tumor immunity by activating STAT3.
IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.
IL22RA1 enhances epithelial barrier function.
IL22RA1 expression is tissue-specific, being high in the liver and skin.
IL22RA1 interacts with IL-10R2 and IL-20RB.
IL22 has high affinity for IL22RA1.
IL22RA1 has multiple alternative splicing variants.
Customer Reviews (3)Write a review
High stability in serum. -
Suitable for receptor binding. -
Effective in autoimmune studies. -
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