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Recombinant Human IL22RA1 protein, His-Avi-tagged

Cat.No. : IL22RA1-120H
Product Overview : Recombinant Human IL-22R alpha 1 Protein is expressed from mammalian with a His and Avi tag at the C-terminal. It contains Ala16-Thr228.
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Description : IL-22 receptor, also known as IL-22 R alpha 1 and CRF2-9, is an approximately 65 kDa transmembrane glycoprotein in the type II cytokine receptor family (CRF).Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
Source : HEK293
Species : Human
Tag : His&Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 27.3 kDa.Due to glycosylation, the protein migrates to 38-45KDa based on Bis-Tris PAGE result.
Protein length : It contains Ala16-Thr228.
Endotoxin : Less than 1EU per ug by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL22RA1 interleukin 22 receptor, alpha 1 [ Homo sapiens ]
Official Symbol : IL22RA1
Synonyms : CRF2-9; CRF2-9interleukin 22 receptor; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; IL-22 R alpha 1; IL-22 receptor subunit alpha-1; IL22R alpha 1; IL22R; IL22R1; IL22RA1; IL-22Ra1; IL-22R-alpha-1; IL-TIF-R1; interleukin 22 receptor, alpha 1; interleukin-22 receptor subunit alpha-1; zcytoR11
Gene ID : 58985
mRNA Refseq : NM_021258
Protein Refseq : NP_067081
MIM : 605457
UniProt ID : Q8N6P7

Not For Human Consumption!

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Customer Reviews (3)

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12/18/2022

    High stability in serum.

    09/04/2017

      Suitable for receptor binding.

      10/16/2016

        Effective in autoimmune studies.

        Q&As (10)

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        What post-translational modifications occur on IL22RA1? 11/18/2022

        IL22RA1 undergoes phosphorylation.

        How does IL22RA1 contribute to IL22 signaling? 03/01/2022

        IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

        What impact do IL22RA1 polymorphisms have on disease susceptibility? 08/13/2021

        IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

        Is IL22RA1 involved in anti-tumor immunity? 07/01/2021

        IL22RA1 is involved in anti-tumor immunity by activating STAT3.

        How does IL22RA1 expression change in autoimmune diseases? 05/25/2021

        IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

        How does IL22RA1 contribute to epithelial barrier function? 04/28/2021

        IL22RA1 enhances epithelial barrier function.

        Is IL22RA1 expression tissue-specific? 05/21/2020

        IL22RA1 expression is tissue-specific, being high in the liver and skin.

        Does IL22RA1 interact with other receptors? 01/20/2020

        IL22RA1 interacts with IL-10R2 and IL-20RB.

        What is the affinity of IL22 for IL22RA1? 02/13/2016

        IL22 has high affinity for IL22RA1.

        Does IL22RA1 have alternative splicing variants? 01/05/2016

        IL22RA1 has multiple alternative splicing variants.

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