IL22RA1
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Official Full Name
interleukin 22 receptor, alpha 1
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Background
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. -
Synonyms
IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; cytokine receptor classII member 9; cytokine receptor family 2 member 9; IL22R; IL22R1; ILTIF R1 chain; Interleukin 22 Receptor alpha 1; Interleukin 22 Receptor; IL-22RA1; zcytoR11; IL-22R-alpha-1; OTTHUMP00000003073; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; CRF2-9;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL22RA1 Related Articles
- IL22RA1 Related Gene Family
- IL22RA1 Related Research Area
IL22RA1 involved in several pathways and played different roles in them. We selected most pathways IL22RA1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNGR2;TNFRSF9A;IL12RB2;TNFRSF10D;CXCL12;CRFB2;CCL4;IL3RA;KITLG |
| Jak-STAT signaling pathway | IL6R;IL23;IL10RA;JAK2A;IL15RA;IFNA21;OSMR;SOCS2;PIK3R1 |
IL22RA1 has several biochemical functions, for example, interferon receptor activity, interleukin-20 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA1 itself. We selected most functions IL22RA1 had, and list some proteins which have the same functions with IL22RA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interferon receptor activity | CRFB1;IL22RA1;CRFB2 |
| interleukin-20 binding | IL20RA;IL20RB;IL22RA1 |
IL22RA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA1.
IL22; STAT3
- Q&As
- Reviews
Q&As (10)
Ask a questionIL22RA1 undergoes phosphorylation.
IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.
IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.
IL22RA1 is involved in anti-tumor immunity by activating STAT3.
IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.
IL22RA1 enhances epithelial barrier function.
IL22RA1 expression is tissue-specific, being high in the liver and skin.
IL22RA1 interacts with IL-10R2 and IL-20RB.
IL22 has high affinity for IL22RA1.
IL22RA1 has multiple alternative splicing variants.
Customer Reviews (3)
Write a reviewHigh stability in serum. -
Suitable for receptor binding. -
Effective in autoimmune studies. -
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