• Official Full Name

    interleukin 22 receptor, alpha 1

  • Overview

    The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
  • Synonyms

    IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; cytokine receptor classII member 9; cytokine receptor family 2 member 9; IL22R; IL22R1; ILTIF R1 chain; Interleukin 22 Receptor alpha 1; Interleukin 22 Receptor; IL-22RA1; zcytoR11; IL-22R-alpha-1; OTTHUMP00000003073; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; CRF2-9;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Canine
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • C
  • hFc
  • Fc
  • His
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • HlgG1 Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL22RA1-791H Active Recombinant Human IL22RA1, HIgG1 Fc-tagged CHO Fc
Human IL22RA1-735H Active Recombinant Human IL22RA1 Protein, His-tagged Mammalian cells His Pro18-Thr228
Human IL22RA1-780H Active Recombinant Human IL22RA1 protein, hFc-tagged HEK293 hFc His16-Thr228
Human IL22RA1-781H Active Recombinant Human IL22RA1, MIgG2a Fc-tagged CHO Fc
Human IL22RA1-801H Recombinant Human IL22RA1, Fc-tagged CHO Fc
Human IL22RA1-1320H Recombinant Human IL22RA1 protein, His & T7-tagged E.coli His/T7 Gln267~Gly565 (Accession # Q8N6P7)
Human IL22RA1-3603H Recombinant Human IL22RA1 Protein (Gln267-Gly565), N-His tagged E.coli N-His Gln267-Gly565
Human IL22RA1-120H Recombinant Human IL22RA1 protein, His-Avi-tagged HEK293 His-Avi It contains Ala16-Thr228.
Human IL22RA1-4649H Recombinant Human IL22RA1 protein, His-SUMO-tagged E.coli His-SUMO 250-573aa
Human IL22RA1-3149H Recombinant Human IL22RA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL22RA1-121H Recombinant Human IL22RA1 protein, His-tagged HEK293 His His 16 - Thr 228
Human IL22RA1-3149H-B Recombinant Human IL22RA1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Il22ra1-864M Active Recombinant Mouse Il22ra1 Protein, His-tagged Mammalian cells His Thr18-Ala228
Mouse Il22ra1-1321M Recombinant Mouse Il22ra1 protein, His-tagged E.coli His Pro258~Cys552
Mouse Il22ra1-4506M Recombinant Mouse Il22ra1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il22ra1-4506M-B Recombinant Mouse Il22ra1 Protein Pre-coupled Magnetic Beads HEK293
Rat Il22ra1-1116R Recombinant Rat Il22ra1 protein, His-tagged HEK293 His Met1-Ala228
Rat Il22ra1-1322R Recombinant Rat Il22ra1 protein, His & T7-tagged E.coli His/T7 Leu242~Pro485 (Accession# D3ZIM3)
Rat IL22RA1-955R Recombinant Rat IL22RA1 Protein (Met1-Ala228), HlgG1 Fc-tagged HEK293 HlgG1 Fc Met1-Ala228
Canine IL22RA1-175C Active Recombinant Canine IL22RA1, His-tagged Human Cell His Met1-The226
Canine IL22RA1-102C Recombinant Canine IL22RA1, Fc tagged Human Cell His
Canine IL22RA1-768CCL Recombinant Canine IL22RA1 cell lysate Human Cell N/A
Canine IL22RA1-2344C Recombinant Canine IL22RA1 protein(Met1-Thr226), hFc-tagged HEK293 C-hFc Met1-Thr226
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL22RA1 involved in several pathways and played different roles in them. We selected most pathways IL22RA1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL22RA2;GM2002;INHBE;TNFRSF21;KDRL;IL11;CX3CR1;ACKR3B;IL23

IL22RA1 has several biochemical functions, for example, interferon receptor activity, interleukin-20 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA1 itself. We selected most functions IL22RA1 had, and list some proteins which have the same functions with IL22RA1. You can find most of the proteins on our site.

Function Related Protein
interferon receptor activityCRFB2;IL22RA1;CRFB1
interleukin-20 bindingIL20RA;IL22RA1;IL20RB

IL22RA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA1.


Gene Family


Research Area

Related articles

Pant, SD; Verschoor, CP; et al. Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. MAMMALIAN GENOME 22:583-588(2011).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What post-translational modifications occur on IL22RA1? 11/18/2022

IL22RA1 undergoes phosphorylation.

How does IL22RA1 contribute to IL22 signaling? 03/01/2022

IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

What impact do IL22RA1 polymorphisms have on disease susceptibility? 08/13/2021

IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

Is IL22RA1 involved in anti-tumor immunity? 07/01/2021

IL22RA1 is involved in anti-tumor immunity by activating STAT3.

How does IL22RA1 expression change in autoimmune diseases? 05/25/2021

IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

How does IL22RA1 contribute to epithelial barrier function? 04/28/2021

IL22RA1 enhances epithelial barrier function.

Is IL22RA1 expression tissue-specific? 05/21/2020

IL22RA1 expression is tissue-specific, being high in the liver and skin.

Does IL22RA1 interact with other receptors? 01/20/2020

IL22RA1 interacts with IL-10R2 and IL-20RB.

What is the affinity of IL22 for IL22RA1? 02/13/2016

IL22 has high affinity for IL22RA1.

Does IL22RA1 have alternative splicing variants? 01/05/2016

IL22RA1 has multiple alternative splicing variants.

Customer Reviews (3)

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    High stability in serum.


      Suitable for receptor binding.


        Effective in autoimmune studies.

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