• Official Full Name

    interleukin 22 receptor, alpha 1

  • Background

    The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
  • Synonyms

    IL22RA1; interleukin 22 receptor, alpha 1; IL22R, interleukin 22 receptor; interleukin-22 receptor subunit alpha-1; CRF2 9; cytokine receptor classII member 9; cytokine receptor family 2 member 9; IL22R; IL22R1; ILTIF R1 chain; Interleukin 22 Receptor alpha 1; Interleukin 22 Receptor; IL-22RA1; zcytoR11; IL-22R-alpha-1; OTTHUMP00000003073; IL-22 receptor subunit alpha-1; cytokine receptor class-II member 9; CRF2-9;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Canine
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian cells
    • Tag :
    • Fc
    • hFc
    • His
    • His (Fc)
    • Avi
    • His|T7
    • SUMO
    • HlgG1 Fc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Canine IL22RA1-175C Active Recombinant Canine IL22RA1, His-tagged Human Cell His
    Canine IL22RA1-102C Recombinant Canine IL22RA1, Fc tagged Human Cell His
    Canine IL22RA1-768CCL Recombinant Canine IL22RA1 cell lysate Human Cell N/A
    Human IL22RA1-735H Active Recombinant Human IL22RA1 Protein, His-tagged Mammalian cells His
    Human IL22RA1-791H Active Recombinant Human IL22RA1, HIgG1 Fc-tagged CHO Fc
    Human IL22RA1-801H Recombinant Human IL22RA1, Fc-tagged CHO Fc
    Human IL22RA1-780H Active Recombinant Human IL22RA1 protein, hFc-tagged HEK293 hFc
    Human IL22RA1-781H Active Recombinant Human IL22RA1, MIgG2a Fc-tagged CHO Fc
    Human IL22RA1-1320H Recombinant Human IL22RA1 protein, His & T7-tagged E.coli His/T7
    Human IL22RA1-120H Recombinant Human IL22RA1 protein, His-Avi-tagged HEK293 His-Avi
    Human IL22RA1-4649H Recombinant Human IL22RA1 protein, His-SUMO-tagged E.coli His-SUMO
    Human IL22RA1-3149H Recombinant Human IL22RA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human IL22RA1-121H Recombinant Human IL22RA1 protein, His-tagged HEK293 His
    Human IL22RA1-3149H-B Recombinant Human IL22RA1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il22ra1-1321M Recombinant Mouse Il22ra1 protein, His-tagged E.coli His
    Mouse Il22ra1-4506M Recombinant Mouse Il22ra1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il22ra1-864M Active Recombinant Mouse Il22ra1 Protein, His-tagged Mammalian cells His
    Mouse Il22ra1-4506M-B Recombinant Mouse Il22ra1 Protein Pre-coupled Magnetic Beads HEK293
    Rat IL22RA1-955R Recombinant Rat IL22RA1 Protein (Met1-Ala228), HlgG1 Fc-tagged HEK293 HlgG1 Fc
    Rat Il22ra1-1322R Recombinant Rat Il22ra1 protein, His & T7-tagged E.coli His/T7
    Rat Il22ra1-1116R Recombinant Rat Il22ra1 protein, His-tagged HEK293 His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL22RA1 Related Articles
    • IL22RA1 Related Gene Family
    • IL22RA1 Related Research Area

    IL22RA1 involved in several pathways and played different roles in them. We selected most pathways IL22RA1 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionIFNGR2;TNFRSF9A;IL12RB2;TNFRSF10D;CXCL12;CRFB2;CCL4;IL3RA;KITLG
    Jak-STAT signaling pathwayIL6R;IL23;IL10RA;JAK2A;IL15RA;IFNA21;OSMR;SOCS2;PIK3R1

    IL22RA1 has several biochemical functions, for example, interferon receptor activity, interleukin-20 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA1 itself. We selected most functions IL22RA1 had, and list some proteins which have the same functions with IL22RA1. You can find most of the proteins on our site.

    Function Related Protein
    interferon receptor activityCRFB1;IL22RA1;CRFB2
    interleukin-20 bindingIL20RA;IL20RB;IL22RA1

    IL22RA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA1.

    IL22; STAT3

    Pant, SD; Verschoor, CP; et al. Bovine IFNGR2, IL12RB1, IL12RB2, and IL23R polymorphisms and MAP infection status. MAMMALIAN GENOME 22:583-588(2011).
    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    What post-translational modifications occur on IL22RA1? 11/18/2022

    IL22RA1 undergoes phosphorylation.

    How does IL22RA1 contribute to IL22 signaling? 03/01/2022

    IL22RA1 enhances IL22 signaling by forming a complex with IL-10R2.

    What impact do IL22RA1 polymorphisms have on disease susceptibility? 08/13/2021

    IL22RA1 polymorphisms affect disease susceptibility in Crohn's disease.

    Is IL22RA1 involved in anti-tumor immunity? 07/01/2021

    IL22RA1 is involved in anti-tumor immunity by activating STAT3.

    How does IL22RA1 expression change in autoimmune diseases? 05/25/2021

    IL22RA1 expression is upregulated in autoimmune diseases like psoriasis.

    How does IL22RA1 contribute to epithelial barrier function? 04/28/2021

    IL22RA1 enhances epithelial barrier function.

    Is IL22RA1 expression tissue-specific? 05/21/2020

    IL22RA1 expression is tissue-specific, being high in the liver and skin.

    Does IL22RA1 interact with other receptors? 01/20/2020

    IL22RA1 interacts with IL-10R2 and IL-20RB.

    What is the affinity of IL22 for IL22RA1? 02/13/2016

    IL22 has high affinity for IL22RA1.

    Does IL22RA1 have alternative splicing variants? 01/05/2016

    IL22RA1 has multiple alternative splicing variants.

    Customer Reviews (3)

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      High stability in serum. -


        Suitable for receptor binding. -


          Effective in autoimmune studies. -

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