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Recombinant Human IL27RA protein, Fc-tagged

Cat.No. : IL27RA-227H
Product Overview : Recombinant Human IL27RA (Gln33-Arg514) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Interleukin-27 receptor subunit alpha ( IL27RA) is also known as Cytokine receptor WSX-1, Cytokine receptor-like 1, Type I T-cell cytokine receptor (TCCR), ZcytoR1, IL27RA belongs to the type I cytokine receptor family and type 2 subfamily. IL27RA contains three fibronectin type-III domains. IL27RA is highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. IL27RA is receptor for IL27, but requires IL6ST/gp130 to mediate signal transduction in response to IL27. IL27RA involved in the regulation of Th1-type immune responses. IL27RA also appears to be involved in innate defense mechanisms.
Source : HEK293
Species : Human
Tag : Fc
Predicted N Terminal : Gln33
Form : Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 79 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Gln33-Arg514
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL27RA
Official Symbol : IL27RA
Synonyms : IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-27 receptor subunit alpha; T-cell cytokine receptor type 1; type I T-cell cytokine receptor; IL27R
Gene ID : 9466
mRNA Refseq : NM_004843
Protein Refseq : NP_004834
MIM : 605350
UniProt ID : Q6UWB1

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
03/19/2022

    Good stability, stable structure, not easy to deteriorate.

    12/08/2021

      The preparation process is very convenient and suitable for novice operators.

      02/21/2020

        This method is highly sensitive and can detect small amounts of protein.

        Q&As (6)

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        What is the use of Il27ra? 07/02/2022

        In general, Il27ra should be administered by subcutaneous injection. For specific use, follow your doctor's advice and read the drug label carefully.

        What is the action mechanism of Il27ra? 02/10/2022

        Il27ra regulates the function of immune cells by binding to its receptor, inhibiting inflammatory response and enhancing antiviral ability.

        Does the clinical applications of Il27ra? 09/08/2020

        It is mainly used in clinical treatment of immune-related diseases, such as tumors, autoimmune diseases and so on.

        Can Il27ra be used with other drugs? 10/29/2019

        It can be used in conjunction with other medications in certain cases, but be sure to inform your doctor about the medications you are using to avoid the possibility of drug interactions.

        Can Il27ra be used in children? 09/27/2019

        The use of Il27ra in children is not yet clear, please follow the guidance of your doctor.

        What are the side effects of Il27ra? 08/19/2019

        No significant side effects of recombinant Il27ra have been found, but common adverse reactions such as local reactions and anaphylaxis may occur.

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