IL27RA
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Official Full Name
interleukin 27 receptor, alpha
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Background
In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. -
Synonyms
IL27RA; interleukin 27 receptor, alpha; interleukin-27 receptor subunit alpha; CRL1; IL 27R; T cell cytokine receptor type 1; TCCR; WSX 1; WSX1; zcytor1; IL-27RA; IL-27R-alpha; IL-27R subunit alpha; cytokine receptor-like 1; class I cytokine receptor; IL-;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL27RA Related Gene Family
IL27RA involved in several pathways and played different roles in them. We selected most pathways IL27RA participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL27RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | PIK3R5;PIK3R3B;CRFB16;OSMR;PTPN2;IL12BA;IFNB1;IL20RA;PIK3R3 |
IL27RA has several biochemical functions, for example, interleukin-27 receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL27RA itself. We selected most functions IL27RA had, and list some proteins which have the same functions with IL27RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-27 receptor activity | IL6ST;IL27RA |
| transmembrane signaling receptor activity | LGR4;ADCYAP1R1A;TLR1;OR2A4;TLR18;IL27RA;OR4C13;IGSF6;FZD1 |
IL27RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL27RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL27RA.
- Q&As
- Reviews
Q&As (6)
Ask a questionIn general, Il27ra should be administered by subcutaneous injection. For specific use, follow your doctor's advice and read the drug label carefully.
Il27ra regulates the function of immune cells by binding to its receptor, inhibiting inflammatory response and enhancing antiviral ability.
It is mainly used in clinical treatment of immune-related diseases, such as tumors, autoimmune diseases and so on.
It can be used in conjunction with other medications in certain cases, but be sure to inform your doctor about the medications you are using to avoid the possibility of drug interactions.
The use of Il27ra in children is not yet clear, please follow the guidance of your doctor.
No significant side effects of recombinant Il27ra have been found, but common adverse reactions such as local reactions and anaphylaxis may occur.
Customer Reviews (3)
Write a reviewTechniques such as ELISA or flow cytometry can be used to detect IL-27RA concentrations in body fluids or cells. -
Molecular structure of IL-27RA protein was analyzed by crystallography or NMR, and the binding mode and interaction mechanism with IL-27 were revealed. -
The regulation of IL-27RA on cell signal transduction pathway and changes in cell function were evaluated by cell experiments. -
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