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Recombinant Human IL31RA protein, Fc-tagged

Cat.No. : IL31RA-731H
Product Overview : Recombinant Human IL31RA (Ala20-Glu519) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Ala20
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ala20-Glu519
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL31RA
Official Symbol : IL31RA
Synonyms : IL31RA; interleukin 31 receptor A; interleukin-31 receptor subunit alpha; CRL; CRL3; GLM R; Glmr; IL 31RA; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3; GPL; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; MGC125346
Gene ID : 133396
mRNA Refseq : NM_001242636
Protein Refseq : NP_001229565
MIM : 609510
UniProt ID : Q8NI17

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can recombinant IL31RA treat eczema? 12/03/2022

Recombinant IL31RA is promising as a potential treatment for eczema, but further research and clinical trials are needed to confirm its efficacy.

How is the research progress of IL31RA? 09/09/2022

The research of IL31RA is ongoing, and there are some relevant research results, but more experiments are needed to confirm its mechanism of action and clinical application.

Is recombinant IL31RA associated with chronic diseases? 06/30/2021

IL31RA is associated with some chronic diseases, such as asthma and eczema, but the specific mechanism still needs to be further studied.

What are the clinical applications of IL31RA? 08/11/2020

The IL31RA can be used in drug development, possibly in the treatment of allergic diseases, skin inflammation and pain.

Does IL31RA have serious side effects? 03/14/2020

The current research on the side effects of IL31RA is not perfect, but there may be local injection site reactions, mild allergic reactions and other situations.

What is the relationship between IL31RA and immune response? 04/08/2019

This protein is involved in the regulation of immune response and may play an important regulatory role in allergic diseases.

Customer Reviews (3)

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Reviews
08/06/2021

    Sensitivity and accuracy of the experiment were significantly improved by using this protein.

    03/28/2021

      The synthesis process is efficient and reliable, reducing experimental time and cost.

      04/23/2020

        Good stability and is suitable for long-term storage and use.

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