Recombinant Human IL31RA protein, Fc-tagged
Cat.No. : | IL31RA-731H |
Product Overview : | Recombinant Human IL31RA (Ala20-Glu519) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Ala20 |
Form : | Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Ala20-Glu519 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL31RA |
Official Symbol : | IL31RA |
Synonyms : | IL31RA; interleukin 31 receptor A; interleukin-31 receptor subunit alpha; CRL; CRL3; GLM R; Glmr; IL 31RA; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3; GPL; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; MGC125346 |
Gene ID : | 133396 |
mRNA Refseq : | NM_001242636 |
Protein Refseq : | NP_001229565 |
MIM : | 609510 |
UniProt ID : | Q8NI17 |
Products Types
◆ Recombinant Protein | ||
IL31RA-2630M | Recombinant Mouse IL31RA Protein (19-499 aa), His-tagged | +Inquiry |
IL31RA-4515M | Recombinant Mouse IL31RA Protein, His (Fc)-Avi-tagged | +Inquiry |
Il31ra-3520M | Recombinant Mouse Il31ra Protein, Myc/DDK-tagged | +Inquiry |
IL31RA-5191H | Recombinant Human IL31RA Protein, GST-tagged | +Inquiry |
IL31RA-2312H | Recombinant Human IL31RA Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL31RA-854HCL | Recombinant Human IL31RA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (6)
Ask a questionRecombinant IL31RA is promising as a potential treatment for eczema, but further research and clinical trials are needed to confirm its efficacy.
The research of IL31RA is ongoing, and there are some relevant research results, but more experiments are needed to confirm its mechanism of action and clinical application.
IL31RA is associated with some chronic diseases, such as asthma and eczema, but the specific mechanism still needs to be further studied.
The IL31RA can be used in drug development, possibly in the treatment of allergic diseases, skin inflammation and pain.
The current research on the side effects of IL31RA is not perfect, but there may be local injection site reactions, mild allergic reactions and other situations.
This protein is involved in the regulation of immune response and may play an important regulatory role in allergic diseases.
Customer Reviews (3)
Write a reviewSensitivity and accuracy of the experiment were significantly improved by using this protein.
The synthesis process is efficient and reliable, reducing experimental time and cost.
Good stability and is suitable for long-term storage and use.
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