Recombinant Human IL31RA protein, Fc-tagged

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Recombinant Human IL31RA protein, Fc-tagged

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Cat.No. : IL31RA-731H
Product Overview : Recombinant Human IL31RA (Ala20-Glu519) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
Description : Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Ala20
Form : Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Ala20-Glu519
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of IL31RA-731H :

Human IL-31 RA, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Gene Name : IL31RA
Official Symbol : IL31RA
Synonyms : IL31RA; interleukin 31 receptor A; interleukin-31 receptor subunit alpha; CRL; CRL3; GLM R; Glmr; IL 31RA; zcytoR17; IL-31R subunit alpha; cytokine receptor-like 3; class I cytokine receptor; IL-31 receptor subunit alpha; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3; GPL; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; MGC125346
Gene ID : 133396
mRNA Refseq : NM_001242636
Protein Refseq : NP_001229565
MIM : 609510
UniProt ID : Q8NI17

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