Recombinant Human IL6, His-tagged
Cat.No. : | IL6-323H |
Product Overview : | Total 193 AA. MW: 22.05 kDa (calculated). N-Terminal His-tag, 10 extra AA (highlighted). |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL6-323H |
Description : | Interleukin-6 is a multi-functional cytokine that regulates immune responses, acute phase reactions and hematopoiesis, and it may play a central role in host defense mechanisms. IL-6 is usually not produced constitutively by normal cells, but its expression is readily induced by a variety of cytokines, lipopolysaccharide or viral infections. |
Source : | E. coli |
Species : | Human |
Form : | Filtered (0,4 μm) and lyophilized in 0.5 mg/mL in 20mM TRIS, 50mM NaCl, pH 7.5. |
Research topic : | Cytokines and chemokines and related molecules, Energy metabolism and body weight regulation. |
Reconstitution : | Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
Applications : | Western blotting |
Quality Control Test : | BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein. |
Sequences of amino acids : | MKHHHHHHAS VPPGEDSKDV AAPHRQPLTS SERIDKQIRY ILDGISALRK ETCNKSNMCE SSKEALAENN LNLPKMAEKD GCFQSGFNEE TCLVKIITGL LEFEVYLEYL QNRFESSEEQ ARAVQMSTKV LIQFLQKKAK NLDAITTPDP TTNASLLTKL QAQNQWLQDM TTHLILRSFK EFLQSSLRAL RQM |
Storage : | Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C. |
Gene Name : | IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ] |
Official Symbol : | IL6 |
Synonyms : | IL6; interleukin 6 (interferon, beta 2); IFN-beta-2; IL-6; BSF2; BSF-2; HGF; HSF; IFNB2; CDF; Hybridoma growth factor; Interferon beta-2; B-cell stimulatory factor 2; B cell stimulatory factor-2; B-cell differentiation factor; interleukin BSF-2; interleukin-6; CTL differentiation factor; OTTHUMP00000158544; OTTHUMP00000198486; OTTHUMP00000198490 |
Gene ID : | 3569 |
mRNA Refseq : | NM_000600 |
Protein Refseq : | NP_000591 |
MIM : | 147620 |
UniProt ID : | P05231 |
Chromosome Location : | 7q21 |
Pathway : | African trypanosomiasis; Cytokine-cytokine receptor interaction; Graft-versus-host disease; Intestinal immune network for IgA production |
Function : | cytokine activity; growth factor activity; nterleukin-6 receptor binding; contributes to interleukin-6 receptor binding; interleukin-6 receptor binding |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (6)
Ask a questionThe dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.
The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.
Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.
Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.
This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.
The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.
Customer Reviews (3)
Write a reviewAccurate localization and function within the cell.
The binding affinity and affinity constant with the target are high.
Can form a stable micellar structure.
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