Recombinant Human IL9R Protein

Cat.No. : IL9R-5164H
Product Overview : Human IL9R full-length ORF (NP_789743.1) recombinant protein without tag.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
Source : Wheat Germ
Species : Human
Form : Liquid
Molecular Mass : 36.4 kDa
AA Sequence : MHLGSNCCKNGQTLLQRTCHGVSCC GWWFQAARSILGKGPSAQSLAGWTL ESEALRRDMGTWLLACICICTCVCL GVSVTGEGQGPRSRTFTCLTNNILR IDCHWSAPELGQGSSPWLLFTRLLA AHISASCGAVSAPSCCHLRQCSCHL TISPSLSTTACLGGSRSAWWTRSTC PGDTSNISSGHCILTWSISPALEPM TTLLSYELAFKKQEEAWEQAQHRDH IVGVTWLILEAFELDPGFIHEARLR VQMATLEDDVVEEERYTGQWSEWSQ PVCFQAPQRQGPLIPPWGWPGNTLV AVSIFLLLTGPTYLLFKLSPRLGWG PTGPVCC
Applications : Antibody Production
Functional Study
Compound Screening
Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH8.0 containing 2% glycerol.
Gene Name : IL9R interleukin 9 receptor [ Homo sapiens ]
Official Symbol : IL9R
Synonyms : IL9R; interleukin 9 receptor; interleukin-9 receptor; CD129; IL-9R; IL-9 receptor;
Gene ID : 3581
mRNA Refseq : NM_002186
Protein Refseq : NP_002177
MIM : 300007
UniProt ID : Q01113

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can the treatment of cancer with IL9R improve the immune system of patients? 05/01/2022

In pre-clinical trials, the IL9R significantly increased natural killer and CD4 + T cell levels in patients.

What somatic cell therapy-based data updates can recombinant IL9R be used for? 08/18/2021

IL9R may play an important role in the treatment of central nervous system diseases and hematological diseases.

In which tumor therapies are recombinant IL9R most likely to be effective? 12/09/2020

This needs to be further confirmed by large-scale clinical trials.

What techniques are used to study the relationship between IL9R and cancer? 10/24/2020

This can be achieved through in vitro molecular cell techniques and carefully designed in vivo animal models.

Which diseases might be treated by recombinant IL9R? 10/06/2020

There have been no large-scale clinical studies to prove which diseases the recombinant IL9R protein can treat.

Is the expression of IL9R in tumor cells correlated with patient prognosis? 08/25/2019

Some studies have suggested that the expression of IL9R in tumor cells may be associated with patient prognosis.

Customer Reviews (3)

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Reviews
05/10/2022

    IL-9R belongs to the cell membrane receptor family, which includes multiple subunits. Different types of IL-9R may have different structures and involve different signal transduction mechanisms, and these structural properties need to be fully considered during the production process. -

    01/11/2022

      Purification of IL-9R is relatively complex due to its transmembrane structure and complexity. Common purification methods include affinity chromatography, centrifugation, gel filtration and other technologies to obtain high purity IL-9R. -

      02/27/2020

        The biological activity of IL-9R is verified by using methods such as cell culture, cell chemotactic assay, or enzym-linked immunosorbent assay, which can evaluate the binding capacity and signaling effect of IL-9R with its ligand, such as IL-9. -

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