Recombinant Human IL9R Protein
|Product Overview :||Human IL9R full-length ORF (NP_789743.1) recombinant protein without tag.|
- Gene Information
- Related Products
|Description :||The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq|
|Source :||Wheat Germ|
|Molecular Mass :||36.4 kDa|
|AA Sequence :||MHLGSNCCKNGQTLLQRTCHGVSCC GWWFQAARSILGKGPSAQSLAGWTL ESEALRRDMGTWLLACICICTCVCL GVSVTGEGQGPRSRTFTCLTNNILR IDCHWSAPELGQGSSPWLLFTRLLA AHISASCGAVSAPSCCHLRQCSCHL TISPSLSTTACLGGSRSAWWTRSTC PGDTSNISSGHCILTWSISPALEPM TTLLSYELAFKKQEEAWEQAQHRDH IVGVTWLILEAFELDPGFIHEARLR VQMATLEDDVVEEERYTGQWSEWSQ PVCFQAPQRQGPLIPPWGWPGNTLV AVSIFLLLTGPTYLLFKLSPRLGWG PTGPVCC|
|Applications :||Antibody Production
|Usage :||Heating may cause protein aggregation. Please do not heat this product before electrophoresis.|
|Notes :||Best use within three months from the date of receipt of this protein.|
|Storage :||Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.|
|Storage Buffer :||25 mM Tris-HCl of pH8.0 containing 2% glycerol.|
|Gene Name :||IL9R interleukin 9 receptor [ Homo sapiens ]|
|Official Symbol :||IL9R|
|Synonyms :||IL9R; interleukin 9 receptor; interleukin-9 receptor; CD129; IL-9R; IL-9 receptor;|
|Gene ID :||3581|
|mRNA Refseq :||NM_002186|
|Protein Refseq :||NP_002177|
|UniProt ID :||Q01113|
|◆ Recombinant Protein|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
In pre-clinical trials, the IL9R significantly increased natural killer and CD4 + T cell levels in patients.
IL9R may play an important role in the treatment of central nervous system diseases and hematological diseases.
This needs to be further confirmed by large-scale clinical trials.
This can be achieved through in vitro molecular cell techniques and carefully designed in vivo animal models.
There have been no large-scale clinical studies to prove which diseases the recombinant IL9R protein can treat.
Some studies have suggested that the expression of IL9R in tumor cells may be associated with patient prognosis.
Customer Reviews (3)Write a review
IL-9R belongs to the cell membrane receptor family, which includes multiple subunits. Different types of IL-9R may have different structures and involve different signal transduction mechanisms, and these structural properties need to be fully considered during the production process. -
Purification of IL-9R is relatively complex due to its transmembrane structure and complexity. Common purification methods include affinity chromatography, centrifugation, gel filtration and other technologies to obtain high purity IL-9R. -
The biological activity of IL-9R is verified by using methods such as cell culture, cell chemotactic assay, or enzym-linked immunosorbent assay, which can evaluate the binding capacity and signaling effect of IL-9R with its ligand, such as IL-9. -
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