Recombinant Human IMMP2L Protein, GST-tagged

• Cat.No.: IMMP2L-5152H
• Product Overview: Human IMMP2L partial ORF ( NP_115938, 31 a.a. - 102 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The mitochondrial inner membrane peptidase (IMP) complex generates mature, active proteins in the mitochondrial intermembrane space by proteolytically removing the mitochondrial targeting presequence of nuclear-encoded proteins. IMP1 (IMMP1L; MIM 612323) and IMP2 are the catalytic subunits of the IMP complex (Burri et al., 2005 [PubMed 15814844]).[supplied by OMIM
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 33.66 kDa
• AA Sequence: DRVACVARVEGASMQPSLNPGGSQS SDVVLLNHWKVRNFEVHRGDIVSLV SPKNPEQKIIKRVIALEGDIVR
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: IMMP2L
• Synonyms: IMMP2L; IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae); IMP2 inner mitochondrial membrane protease like (S. cerevisiae); mitochondrial inner membrane protease subunit 2; IMP2; inner mitochondrial membrane peptidase 2 like; IMP2-LIKE
• Gene ID: 83943
• mRNA Refseq: NM_001244606
• Protein Refseq: NP_001231535
• MIM: 605977
• UniProt ID: Q96T52

Reviews

06/20/2022

Good consistency, multiple experimental results are highly repeatable.

05/08/2021

Easy to operate, do not need to spend too long to learn to operate, save time.

02/03/2021

The enzyme activity and receptor binding activity were good.

Q&As

Is IMMP2L gene mutation associated with genetic diseases?

The protein found mutations associated with specific genetic diseases, but still need further study to evaluate its potential.

In what tissues or organs IMMP2L high expression?

IMMP2L is expressed in many tissues and organs, especially in the heart, muscle and nervous system.

Is there a relationship between IMMP2L abnormal expression and tumorigenesis?

The relationship between the abnormal expression of IMMP2L and tumorigenesis has not been found, and further studies are still needed.

What is the regulatory mechanism of IMMP2L?

The regulatory mechanism of IMMP2L is regulated by a variety of factors, including signaling pathways, transcription factors, and protein interactions.

What diseases is IMMP2L associated with?

At present has not yet been determined IMMP2L and the correlation between the specific diseases, but with mitochondrial dysfunction and metabolic diseases such as possible.

What is the function of IMMP2L?

It is involved in the assembly of peptidase complexes in the inner mitochondrial membrane and plays an important role in protein maturation and regulation.