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Recombinant Human ING3 Protein, GST-tagged

Cat.No. : ING3-5129H
Product Overview : Human ING3 full-length ORF ( AAH09776, 1 a.a. - 92 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 35.86 kDa
AA Sequence : MLYLEDYLEMIEQLPMDLRDRFTEM REMDLQVQNAMDQLEQRVSEFFMNA KKNKPEWREEQMASIKKDYYKALED ADEKVQLANQIYDLQHF
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ING3 inhibitor of growth family, member 3 [ Homo sapiens ]
Official Symbol : ING3
Synonyms : ING3; inhibitor of growth family, member 3; inhibitor of growth protein 3; Eaf4; FLJ20089; MEAF4; p47ING3; ING2;
Gene ID : 54556
mRNA Refseq : NM_019071
Protein Refseq : NP_061944
MIM : 607493
UniProt ID : Q9NXR8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What specific modification does ING3 recognize on histones, and where is this recognition mediated? 10/04/2022

ING3 recognizes histone H3 trimethylated at Lysine 4 (H3K4me3) through the Plant HomeoDomain (PHD) present at its C-terminal region.

What structural similarity was observed between ING3’s PHD and that of its homologs? 11/06/2019

The crystal structure of ING3’s PHD showed similarity to the PHD domains of its four homologs, suggesting a common structural motif among them.

What enzymatic activity does ING3 facilitate regarding histones H2A and H4? 10/04/2018

ING3 facilitates acetylation of histones H2A and H4 by interacting with the NuA4-Tip60 MYST histone acetyltransferase complex.

How does the PHD of ING3 interact with histone H3K4me3? 07/23/2018

The PHD of ING3 binds histone H3K4me3 with low-micromolar affinity, while its affinity for non-methylated histone is reduced by 54-fold.

What insights do these structural features provide regarding ING3 mutations in tumors? 06/17/2017

The structural features explain the possible deleterious effects of ING3 mutations detected in tumors, which may disrupt its histone recognition and functional roles.

How has ING3 been characterized in relation to cancer? 08/23/2016

ING3 has been proposed to be an oncoprotein, suggesting its potential involvement in tumorigenesis.

What structural features were observed in the crystal structure of ING3’s N-terminal domain? 03/05/2016

The crystal structure of the N-terminal domain of ING3 revealed that it forms homodimers with an antiparallel coiled-coil fold.

Customer Reviews (3)

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Reviews
05/15/2022

     The product’s unique attributes propelled our research to innovative heights.

    09/08/2020

      Dependable protein-protein interaction outcomes were achieved due to the product's pure composition.

      09/16/2018

         The product consistently met our expectations, reinforcing the credibility of our findings.

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