Recombinant Human ING3 Protein, GST-tagged
Cat.No. : | ING3-5129H |
Product Overview : | Human ING3 full-length ORF ( AAH09776, 1 a.a. - 92 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 35.86 kDa |
AA Sequence : | MLYLEDYLEMIEQLPMDLRDRFTEM REMDLQVQNAMDQLEQRVSEFFMNA KKNKPEWREEQMASIKKDYYKALED ADEKVQLANQIYDLQHF |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ING3 inhibitor of growth family, member 3 [ Homo sapiens ] |
Official Symbol : | ING3 |
Synonyms : | ING3; inhibitor of growth family, member 3; inhibitor of growth protein 3; Eaf4; FLJ20089; MEAF4; p47ING3; ING2; |
Gene ID : | 54556 |
mRNA Refseq : | NM_019071 |
Protein Refseq : | NP_061944 |
MIM : | 607493 |
UniProt ID : | Q9NXR8 |
Products Types
◆ Recombinant Protein | ||
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ING3-2719R | Recombinant Rat ING3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ING3-2434C | Recombinant Chicken ING3 | +Inquiry |
ING3-3884H | Recombinant Human ING3 protein, His-tagged | +Inquiry |
◆ Lysates | ||
ING3-5207HCL | Recombinant Human ING3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionING3 recognizes histone H3 trimethylated at Lysine 4 (H3K4me3) through the Plant HomeoDomain (PHD) present at its C-terminal region.
The crystal structure of ING3’s PHD showed similarity to the PHD domains of its four homologs, suggesting a common structural motif among them.
ING3 facilitates acetylation of histones H2A and H4 by interacting with the NuA4-Tip60 MYST histone acetyltransferase complex.
The PHD of ING3 binds histone H3K4me3 with low-micromolar affinity, while its affinity for non-methylated histone is reduced by 54-fold.
The structural features explain the possible deleterious effects of ING3 mutations detected in tumors, which may disrupt its histone recognition and functional roles.
ING3 has been proposed to be an oncoprotein, suggesting its potential involvement in tumorigenesis.
The crystal structure of the N-terminal domain of ING3 revealed that it forms homodimers with an antiparallel coiled-coil fold.
Customer Reviews (3)
Write a reviewThe product’s unique attributes propelled our research to innovative heights.
Dependable protein-protein interaction outcomes were achieved due to the product's pure composition.
The product consistently met our expectations, reinforcing the credibility of our findings.
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