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Recombinant Human Interferon, Alpha 2, His-tagged

Cat.No. : IFNA2-17H
Product Overview : Recombinant Human Interferon Alpha 2a produced in Plant is a single, glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 19 kDa. The Interferon-2a contains affinity 6xHis tag on C-terminus. The IFN-A2a is purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : IFNA2-17H
Description : IFN-alpha is produced by macrophages and has antiviral activities. Interferon stimulates the production of two enzymes: protein kinase and an oligoadenylate synthetase.
Source : Nicotiana Sp.Plant.
Amino Acid Sequence : The sequence of the first twelve N-terminal amino acids was determined and was found to be Cys-Asp-Leu-Pro-Gln-Thr-His-Ser-Leu-Gly-Ser-Arg.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 99.0% as determined by both: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation : Lyophilized, containing 50% SDS.
Solubility : It is recommended to reconstitute the lyophilized Interferon-alpha 2a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity : The specific activity was determined by a quantitative gene report bioassay using human Type I interferon-sensitive cells. Compared with bacterial derived recombinant IFN-a 2a, assayed in the same conditions, plant derived IFN-alpha 2a showed 6.1 × 108Units/mg in reference to a viral resistance assay using bovine kidney MDBK cells.
Storage : Lyophilized Interferon alpha 2a although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution IFN-alpha 2a should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : IFNA2 interferon, alpha 2 [ Homo sapiens ]
Synonyms : IFNA2; Interferon, Alpha 2; IFNA; INFA2; MGC125764; MGC125765; Interferon alpha A; Alpha-2a interferon; Interferon alpha 2b; OTTHUMP00000021143; Interferon alpha-A; LeIF A; Interferon, alpha-2
Gene ID : 3440
mRNA Refseq : NM_000605
Protein Refseq : NP_000596
MIM : 147562
UniProt ID : P01563
Chromosome Location : 9p22
Pathway : Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; RIG-I-like receptor signaling pathway; Regulation of autophagy; Toll-like receptor signaling pathway; Antigen processing and presentation
Function : cytokine activity; interferon-alpha/beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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