Recombinant Human Interleukin 17C, His-tagged
|Product Overview :||Recombinant human IL-17C with His-tag was expressed inInsect cell.MW= 19.793 kDa.|
- Gene Information
- Related Products
|Cat. No. :||IL17C-291H|
|Description :||IL-17C is a member of the IL-17 family, which is comprised of six proteins (IL-17A through IL-17F). IL-17 proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. IL-17C has been reported to stimulate the release of TNF-alpha and IL-1β from the monocytic cell line THP-1. IL-17C shares 15% to 30% amino acid sequence identity with the other IL-17 family members. Mouse and human IL-17C share 83% amino acid sequence identity. Human IL-17C cDNA encodes a 197 amino acid protein with a putative 18 amino acid signal peptide. The recombinant human IL-17C is a disulfide-linked homodimer composed of a 19.8 kDa monomeric subunit.|
|Source :||Insect cell.|
|Handling Conditions :||For best recovery, quick-spin vial prior to opening. Use in a sterile environment.|
|Purity :||Greater than 98% as determined by SDS-PAGE.|
|Endotoxin Level :||Less than 0.01 ng/ug cytokine as determined by the LAL assay.|
|Bioactivity :||Testing in progress.|
|Formulation :||20 mM Phosphate, 0.2 M NaCl, pH 6.0, with 1.0% BSA.|
|Temperature Limitation :||Store at less than or equal to –70°C.|
|Gene Name :||IL17C interleukin 17C [ Homo sapiens ]|
|Synonyms :||interleukin 17C; CX2; IL-21; IL-17C; MGC126884; MGC138401; IL17C; interleukin-17C; cytokine CX2; Cytokine CX2|
|Gene ID :||27189|
|mRNA Refseq :||NM_013278|
|Protein Refseq :||NP_037410|
|UniProt ID :||Q9P0M4|
|Chromosome Location :||16q24|
|Function :||cytokine activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Animal models, patient biopsies, and genetic association studies reveal IL17C's role in autoimmune diseases.
Combination cytokine stimulation assays and signaling pathway inhibitors elucidate IL17C's crosstalk.
Xenograft models and tumor growth measurements uncover IL17C's contribution to cancer progression.
Flow cytometry analysis with cell-specific markers characterizes IL17C's impact on immune cell subsets.
Neutralizing antibodies and RNA interference validate IL17C's potential as a therapeutic target.
Infection models, bacterial challenges, and mucosal sampling assess IL17C's role in host defense.
Chemotaxis assays and confocal microscopy study IL17C-mediated immune cell recruitment.
Organoid culture systems and cytokine measurements explore IL17C's impact on epithelial barrier function.
Co-immunoprecipitation and mass spectrometry identify IL17C interactors and signaling molecules.
Comparative functional assays and gene knockout models distinguish IL17C's unique roles.
Customer Reviews (3)Write a review
High purity levels. -
Potent in anti-fungal assays. -
Suitable for receptor binding studies. -
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