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Recombinant Human Interleukin 21 Receptor

Cat.No. : IL21R-1659H
  • Specification
  • Gene Information
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Cat. No. : IL21R-1659H
Description : Interleukin 21 receptor is a type I cytokine receptor. The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-21 R is Mr 51.7 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 80-85 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : IL21R interleukin 21 receptor [ Homo sapiens ]
Synonyms : IL21R; interleukin 21 receptor; NILR; MGC10967; IL-21R; Novel interleukin receptor; Interleukin-21 receptor; IL-21R
Gene ID : 50615
mRNA Refseq : NM_021798
Protein Refseq : NP_068570
MIM : 605383
UniProt ID : Q9HBE5
Chromosome Location : 16p11
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : interleukin-21 receptor activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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