Recombinant Human IRAK4 protein(Met1-Ser336), His-tagged

Cat.No. : IRAK4-1107H
Product Overview : Recombinant Human IRAK4 (Q9NWZ3-2) (Met1-Ser336) was expressed in Insect Cells with a polyhistidine tag at the C-terminus.
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Source : Insect Cells
Species : Human
Tag : C-His
Protein length : Met1-Ser336
Form : Lyophilized from sterile 20mM PB, 300mM NaCl, 10%glycerol, 0.5mM TCEP, pH7.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human IRAK4 consists of 355 amino acids and predicts a molecular mass of 40.01 kDa. It migrates as an approximately 42.82 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ]
Official Symbol : IRAK4
Synonyms : IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64; renal carcinoma antigen NY-REN-64; IPD1; REN64; IRAK-4; NY-REN-64;
Gene ID : 51135
mRNA Refseq : NM_001114182
Protein Refseq : NP_001107654
MIM : 606883
UniProt ID : Q9NWZ3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What conditions are associated with IRAK4 dysregulation? 11/04/2020

Rheumatoid arthritis, lupus, inflammatory bowel diseases, and certain cancers may involve IRAK4.

Are there any ongoing clinical trials involving IRAK4 inhibitors? 10/07/2020

Yes, several trials are investigating IRAK4 inhibitors' effectiveness and safety in various diseases.

What are the methods used to target IRAK4 in treatment? 11/25/2017

Small molecule inhibitors and monoclonal antibodies are primary methods for modulating IRAK4 activity.

How does the expression of IRAK4 differ in healthy individuals and those with autoimmune diseases? 11/01/2016

Individuals with autoimmune diseases often show increased IRAK4 expression compared to healthy individuals.

How does IRAK4 inhibition impact the immune response? 01/17/2016

By blocking IRAK4, the overactive immune response in certain diseases can be suppressed.

Customer Reviews (3)

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11/16/2021

    Its potency and specificity make it a valuable tool for studying specific biological pathways or mechanisms.

    03/01/2020

      Their technical expertise and experience in the field allow them to provide invaluable guidance and assistance.

      07/16/2018

        They can offer insights on experimental design, optimal usage protocols, and troubleshoot any challenges that may arise during the course of the trial.

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