| Description : |
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
119.48 kDa |
| AA Sequence : |
MAAAGQLCLLYLSAGLLSRLGAAFN LDTREDNVIRKYGDPGSLFGFSLAM HWQLQPEDKRLLLVGAPRAEALPLQ RANRTGGLYSCDITARGPCTRIEFD NDADPTSESKEDQWMGVTVQSQGPG GKVVTCAHRYEKRQHVNTKQESRDI FGRCYVLSQNLRIEDDMDGGDWSFC DGRLRGHEKFGSCQQGVAATFTKDF HYIVFGAPGTYNWKGIVRVEQKNNT FFDMNIFEDGPYEVGGETEHDESLV PVPANSYLGFSLDSGKGIVSKDEIT FVSGAPRANHSGAVVLLKRDMKSAH LLPEHIFDGEGLASSFGYDVAVVDL NKDGWQDIVIGAPQYFDRDGEVGGA VYVYMNQQGRWNNVKPIRLNGTKDS MFGIAVKNIGDINQDGYPDIAVGAP YDDLGKVFIYHGSANGINTKPTQVL KGISPYFGYSIAGNMDLDRNSYPDV AVGSLSDSVTIFRSRPVINIQKTIT VTPNRIDLRQKTACGAPSGICLQVK SCFEYTANPAGYNPSISIVGTLEAE KERRKSGLSSRVQFRNQGSEPKYTQ ELTLKRQKQKVCMEETLWLQDNIRD KLRPIPITASVEIQEPSSRRRVNSL PEVLPILNSDEPKTAHIDVHFLKEG CGDDNVCNSNLKLEYKFCTREGNQD KFSYLPIQKGVPELVLKDQKDIALE ITVTNSPSNPRNPTKDGDDAHEAKL IATFPDTLTYSAYRELRAFPEKQLS CVANQNGSQADCELGNPFKRNSNVT FYLVLSTTEVTFDTPDLDINLKLET TSNQDNLAPITAKAKVVIELLLSVS GVAKPSQVYFGGTVVGEQAMKSEDE VGSLIEYEFRVINLGKPLTNLGTAT LNIQWPKEISNGKWLLYLVKVESKG LEKVTCEPQKEINSLNLTESHNSRK KREITEKQIDDNRKFSLFAERKYQT LNCSVNVNCVNIRCPLRGLDSKASL ILRSRLWNSTFLEEYSKLNYLDILM RAFIDVTAAAENIRLPNAGTQVRVT VFPSKTVAQYSGVPWWIILVAILAG ILMLALLVFILWKCGFFKRNKKDHY DATYHKAEIHAQPSDKERLTSDATR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
