Recombinant Human ITGAM&ITGB2 protein, His-tagged

• Cat.No.: ITGAM&ITGB2-0240H
• Product Overview: Recombinant Human ITGAM&ITGB2 protein(Phe17-Asn1105(ITGAM)&Gln23-Asn700(ITGB2)), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.
• Molecular Mass: Subunit ITGAM is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 150-180 kDa (ITGAM) and 85-95 kDa (ITGB2) respectively due to glycosylation.
• Proteinlength: Phe17-Asn1105(ITGAM)&Gln23-Asn700(ITGB2)
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term, the product should be stored at lyophilized state at -20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after at:
  -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) [ Homo sapiens ]
• Official Symbol: ITGAM
• Synonyms: ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CD11B, CR3A, integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide); integrin alpha-M; CD11b; MAC 1; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit; CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; MGC117044
• Gene ID: 3684
• mRNA Refseq: NM_000632
• Protein Refseq: NP_000623
• MIM: 120980
• UniProt ID: P11215

Reviews

12/10/2022

Reliable data for credibility. Trusted for results.

02/27/2022

Timely and precise results. Accelerates our research timelines.

06/27/2018

Efficient and dependable service. Enhances research quality.

Q&As

How does ITGAM contribute to the adhesion and migration of leukocytes?

It facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.

What potential therapeutic applications arise from targeting ITGAM in immune-related disorders?

Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.

How do genetic variations in ITGAM affect immune responses and susceptibility to autoimmune diseases?

Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.

What role does ITGAM play in the immune system's response to infection?

ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.

How does ITGAM interact with other components of the immune system?

ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.

What is the primary role of ITGAM in immune cell function?

ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.

What is the impact of altered ITGAM activity on inflammatory processes?

Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.