Recombinant Human ITM2C Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human ITM2C Protein, Myc/DDK-tagged, C13 and N15-labeled

ITM2C Related Products

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Cat.No. : ITM2C-2959H
Product Overview : ITM2C MS Standard C13 and N15-labeled recombinant protein (NP_001012532) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 25 kDa
AA Sequence : MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR LARDNFFRCG VLYEDSLSSQ VRTQMELEED VKIYLDENYE RINVPVPQFG GGDPADIIHD FQRGLTAYHD ISLDKCYVIE LNTTIVLPPR NFWELLMNVK RGTYLPQTYI IQEEMVVTEH VSDKEALGSF IYHLCNGKDT YRLRRRATRR RINKRGAKNC NAIRHFENTF VVETLICGVV TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : ITM2C integral membrane protein 2C [ Homo sapiens (human) ]
Official Symbol : ITM2C
Synonyms : ITM2C; integral membrane protein 2C; BRI3; E25; hRPC.1050_D_4; ITM3; E25C; HRPC.1050_D_4;
Gene ID : 81618
mRNA Refseq : NM_001012514
Protein Refseq : NP_001012532
MIM : 609554
UniProt ID : Q9NQX7

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