Recombinant Human IYD, His-tagged
Cat.No. : | IYD-5096H |
Product Overview : | Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli. |
- Specification
- Gene Information
- Related Products
Description : | IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol |
Molecular Mass : | 25.1kDa (214aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20centigrade or -70centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | IYD iodotyrosine deiodinase [ Homo sapiens (human) ] |
Official Symbol : | IYD |
Synonyms : | IYD;TDH4; DEHAL1; C6orf71; dJ422F24.1;iodotyrosine dehalogenase 1;IYD-1 |
Gene ID : | 389434 |
mRNA Refseq : | NM_001164694.1 |
Protein Refseq : | NP_001158166.1 |
MIM : | 612025 |
UniProt ID : | Q6PHW0 |
Chromosome Location : | 6q25.1 |
Pathway : | Amine-derived hormones;Metabolism;Metabolism of amino acids and derivatives;Thyroid hormone synthesis;Thyroid hormone synthesis;Thyroxine biosynthesis |
Function : | oxidoreductase activity |
Products Types
◆ Recombinant Protein | ||
IYD-4938H | Recombinant Human IYD Protein, GST-tagged | +Inquiry |
IYD-2788R | Recombinant Rat IYD Protein, His (Fc)-Avi-tagged | +Inquiry |
IYD-4663M | Recombinant Mouse IYD Protein, His (Fc)-Avi-tagged | +Inquiry |
IYD-495H | Recombinant Human iodotyrosine deiodinase, His-tagged | +Inquiry |
IYD-8401M | Recombinant Mouse IYD Protein | +Inquiry |
◆ Lysates | ||
IYD-885HCL | Recombinant Human IYD cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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