| Description : |
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Supplied as a 0.2 μm filtered solution in PBS, pH 7.4 |
| Molecular Mass : |
~ 95 kDa, reducing condition. |
| AA Sequence : |
MSEAGGAGPGGCGAGAGAGAGPGAL PPQPAALPPAPPQGSPCAAAAGGSG ACGPATAVAAAGTAEGPGGGGSARI AVKKAQLRSAPRAKKLEKLGVYSAC KAEESCKCNGWKNPNPSPTPPRADL QQIIVSLTESCRSCSHALAAHVSHL ENVSEEEMNRLLGIVLDVEYLFTCV HKEEDADTKQVYFYLFKLLRKSILQ RGKPVVEGSLEKKPPFEKPSIEQGV NNFVQYKFSHLPAKERQTIVELAKM FLNRINYWHLEAPSQRRLRSPNDDI SGYKENYTRWLCYCNVPQFCDSLPR YETTQVFGRTLLRSVFTVMRRQLLE QARQEKDKLPLEKRTLILTHFPKFL SMLEEEVYSQNSPIWDQDFLSASSR TSQLGIQTVINPPPVAGTISYNSTS SSLEQPNAGSSSPACKASSGLEANP GEKRKMTDSHVLEEAKKPRVMGDIP MELINEVMSTITDPAAMLGPETNFL SAHSARDEAARLEERRGVIEFHVVG NSLNQKPNKKILMWLVGLQNVFSHQ LPRMPKEYITRLVFDPKHKTLALIK DGRVIGGICFRMFPSQGFTEIVFCA VTSNEQVKGYGTHLMNHLKEYHIKH DILNFLTYADEYAIGYFKKQGFSKE IKIPKTKYVGYIKDYEGATLMGCEL NPRIPYTEFSVIIKKQKEIIKKLIE RKQAQIRKVYPGLSCFKDGVRQIPI ESIPGIRETGWKPSGKEKSKEPRDP DQLYSTLKSILQQVKSHQSAWPFME PVKRTEAPGYYEVIRFPMDLKTMSE RLKNRYYVSKKLFMADLQRVFTNCK EYNPPESEYYKCANILEKFFFSKIK EAGLIDKHHHHHHHHHH |
| Endotoxin : |
Less than 1.0 EU per ug by the LAL method |
| Purity : |
>80%, by SDS-PAGE |
| Storage : |
Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : |
0.1 mg/ml |
