| Description : |
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
29.6 kDa |
| AA Sequence : |
MSDPITLNVGGKLYTTSLATLTSFP DSMLGAMFSGKMPTKRDSQGNCFID RDGKVFRYILNFLRTSHLDLPEDFQ EMGLLRREADFYQVQPLIEALQEKE VELSKAEKNAMLNITLNQRVQTVHF TVREAPQIYSLSSSSMEVFNANIFS TSCLFLKLLGSKLFYCSNGNLSSIT SHLQDPNHLTLDWVANVEGLPEEEY TKQNLKRLWVVPANKQINSFQVFVE EVLKIALSDGFCIDSSHPHALDFMN NKIIRLIRYRTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
