Recombinant Human KDR Protein, His-tagged

• Cat.No.: KDR-070H
• Product Overview: Recombinant protein from the second and third Ig-like C2-type domains (D120-T320) of homo sapiens kinase insert domain receptor (a type III receptor tyrosine kinase) (KDR) (NM_002253), with a polyhistidine tag was expressed in human cells.

Specification

• Description: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
• Source: Human cells
• Species: Human
• Tag: His
• Molecular Mass: 25.1 kDa
• Endotoxin: Endotoxin level is < 0.1 ng/μg of protein (< 1 EU /μg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies; For research & development use only!
• Storage Buffer: Purified protein formulated in a sterile solution of PBS buffer, pH7.2, without any preservatives

Gene Information

• Gene Name: KDR kinase insert domain receptor [ Homo sapiens (human) ]
• Official Symbol: KDR
• Synonyms: KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; fetal liver kinase-1; kinase insert domain receptor (a type III receptor tyrosine kinase); protein-tyrosine kinase receptor Flk-1; soluble VEGFR2; tyrosine kinase growth factor receptor; EC 2.7.10.1
• Gene ID: 3791
• mRNA Refseq: NM_002253
• Protein Refseq: NP_002244
• MIM: 191306
• UniProt ID: P35968