Recombinant Human KEAP1 protein, MYC/DDK-tagged
Cat.No. : | KEAP1-652H |
Product Overview : | Recombinant Human KEAP1, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
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Description : | This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 69.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | KEAP1 kelch-like ECH-associated protein 1 [ Homo sapiens ] |
Official Symbol : | KEAP1 |
Synonyms : | KEAP1; kelch-like ECH-associated protein 1; INrf2; KIAA0132; KLHL19; MGC1114; MGC4407; MGC9454; MGC10630; MGC20887; kelch-like protein 19; cytosolic inhibitor of Nrf2; |
Gene ID : | 9817 |
mRNA Refseq : | NM_203500 |
Protein Refseq : | NP_987096 |
MIM : | 606016 |
UniProt ID : | Q14145 |
Chromosome Location : | 19p13.2 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Keap1-Nrf2 Pathway, organism-specific biosystem; |
Function : | protein binding; |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionKEAP1 acts as a sensor for oxidative stress by interacting with NRF2. When cells experience oxidative stress, KEAP1 releases NRF2, allowing it to translocate into the nucleus and initiate the expression of various cytoprotective genes.
Post-translational modifications such as phosphorylation, ubiquitination, and acetylation control the interaction between KEAP1 and NRF2, influencing NRF2's stability and activity.
One challenge is the need for specific targeting without causing adverse effects on normal cell function, as NRF2 has both protective and potentially harmful effects.
Researchers are exploring small molecules that modulate the KEAP1-NRF2 interaction, aiming to enhance NRF2 activation for therapeutic benefit in conditions where oxidative stress plays a significant role.
Yes, there are clinical trials investigating drugs that target the KEAP1-NRF2 pathway in cancer treatment, especially for lung and pancreatic cancers.
Customer Reviews (3)
Write a reviewThis protein demonstrates exceptional performance in ELISA, delivering accurate and reliable results in the detection and quantification of specific antigens.
KEAP1 protein has proven to be instrumental in protein electron microscopy structure analysis.
With KEAP1 protein, researchers can visualize protein complexes and their interactions with remarkable clarity, unraveling important insights into their functional mechanisms.
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