Recombinant Human Keratin 15

• Cat.No.: KRT15-7982TH
• Product Overview: Recombinant Human Cytokeratin protein (amino acids 1-456) , fused with proprietary tag was expressed in Wheat germ.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 1-456 a.a.
• Description: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2.
• Proteinlength: 456 amino acids
• Form: Liquid
• Storage instructions: Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
• Storage buffer: pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl
• Concentration: 10 µg at 0.05 mg/ml
• Additional notes: Protein concentration is above or equal to 0.05 mg/ml.
• Sequence notes: MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGYGGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIGIREASSGGGGSSSNFHINV EESVDGQVVSSHKREI
• Application: WB; ELISA
• Tissue specificity: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.
• Sequencesimilarities: Belongs to the intermediate filament family.
• OfficialSymbol: KRT15

Gene Information

• Gene Name: KRT15 keratin 15 [ Homo sapiens ]
• Synonyms: KRT15; keratin 15; keratin, type I cytoskeletal 15; CK15; cytokeratin 15; K1CO; K15; basic; beta; type I cytoskeletal 15; CK-15; cytokeratin-15; keratin-15, beta; keratin-15, basic
• Gene ID: 3866
• mRNA Refseq: NM_002275
• Protein Refseq: NP_002266
• MIM: 148030
• UniProt ID: P19012
• Chromosome Location: 17q21.2
• Function: protein binding; structural constituent of cytoskeleton; scaffold protein binding