| Description : |
This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac (BTB) domain that facilitates protein binding and dimerization, a BTB and C-terminal kelch (BACK) domain, and six C-terminal kelch repeat domains. Naturally occurring mutations in this gene are associated with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
69.2 kDa |
| AA Sequence : |
MGDVVEKSLEGPLAPSTDEPSQKTG DLVEILNGEKVKFDDAGLSLILQNG LETLRMENALTDVILCVDIQEFSCH RVVLAAASNYFRAMFCNDLKEKYEK RIIIKGVDAETMHTLLDYTYTSKAL ITKQNVQRVLEAANLFQFLRMVDAC ASFLTEALNPENCVGILRLADTHSL DSLKKQVQSYIIQNFVQILNSEEFL DLPVDTLHHILKSDDLYVTEEAQVF ETVMSWVRHKPSERLCLLPYVLENV RLPLLDPWYFVETVEADPLIRQCPE VFPLLQEARMYHLSGNEIISERTKP RMHEFQSEVFMIIGGCTKDERFVAE VTCLDPLRRSRLEVAKLPLTEHELE SENKKWVEFACVTLKNEVYISGGKE TQHDVWKYNSSINKWIQIEYLNIGR WRHKMVVLGGKVYVIGGFDGLQRIN NVETYDPFHNCWSEAAPLLVHVSSF AATSHKKKLYVIGGGPNGKLATDKT QCYDPSTNKWSLKAAMPVEAKCINA VSFRDRIYVVGGAMRALYAYSPLED SWCLVTQLSHERASCGIAPCNNRLY ITGGRDEKNEVIATVLCWDPEAQKL TEECVLPRGVSHHGSVTIRKSYTHI RRIVPGAVSVTRTRPLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
