"KLK2" Related Products


Recombinant Human KLK2 protein, His-tagged

Cat.No.: KLK2-152H
Product Overview: Recombinant Human KLK2(Met1-Pro261) fused with His tag at C-terminal was expressed in NS0.
Description: Kallikrein 2 (KLK2) is a secreted serine protease that is highly expressed in the human prostate gland. It is also known as the prostate-specific glandular kallikrein. The enzyme is highly specific for cleavage after arginine residues. KLK2 is able to activate the urokinase-type plasminogen activator. KLK2 is inhibited by serpins such as protein C inhibitor, antichymotrypsin, and plasminogen activator inhibitor 1. KLK2 is structurally related to KLK3, the prostate-specific antigen (PSA). Like PSA, KLK2 is considered to be a biomarker for prostate cancer.
Source: NS0
Species: Human
Tag: His
Predicted N Terminal: Ile25 & Leu124
Form: Supplied as a 0.2 μm filtered solution in Sodium Citrate and NaCl.
Bio-activity: Measured by its ability to cleave a flourogenic peptide substrate Pro-Phe-Arg-7-amido-4-methylcoumarin (PFR-AMC). The specific activity is >125 pmol/min/μg.
Molecular Mass: Predicted Molecular Mass: 28 & 16 kDa;SDS-PAGE: 34 kDa & 15-18 kDa, reducing conditions.
Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >85%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane
Storage: Avoid repeated freeze-thaw cycles.6 months from date of receipt, -70 centigrade as supplied.3 months, -70 centigrade under sterile conditions after opening.
Gene Name: KLK2 kallikrein-related peptidase 2 [ Homo sapiens ]
Official Symbol: KLK2
Synonyms: KLK2; kallikrein-related peptidase 2; kallikrein 2, prostatic; kallikrein-2; tissue kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; hK2; hGK-1; KLK2A2; FLJ17010; FLJ17011; MGC12201;
Gene ID: 3817
mRNA Refseq: NM_001002231
Protein Refseq: NP_001002231
MIM: 147960
UniProt ID: P20151
Chromosome Location: 19q13.33
Pathway: Activation of Matrix Metalloproteinases, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; Extracellular matrix organization, organism-specific biosystem
Function: peptidase activity; serine-type endopeptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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