Recombinant Human KLK6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human KLK6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : KLK6-2520H
Product Overview : KLK6 MS Standard C13 and N15-labeled recombinant protein (NP_002765) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 26.86 kDa
AA Sequence : MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAKTRTRPL EQKLISEEDL AANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : KLK6 kallikrein-related peptidase 6 [ Homo sapiens (human) ]
Official Symbol : KLK6
Synonyms : KLK6; kallikrein-related peptidase 6; kallikrein 6 (neurosin, zyme), protease, serine, 18, PRSS9, PRSS18; kallikrein-6; Bssp; Klk7; neurosin; zyme; protease M; serine protease 9; serine protease 18; hK6; SP59; PRSS9; PRSS18; MGC9355;
Gene ID : 5653
mRNA Refseq : NM_002774
Protein Refseq : NP_002765
MIM : 602652
UniProt ID : Q92876

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