Recombinant Human KLRB1 Protein, C-His-tagged

• Cat.No.: KLRB1-087H
• Product Overview: Recombinant Human KLRB1 Protein with C-His tag was expressed in E. coli.

Specification

• Description: CD161/KLRB1 (Killer cell lectin-like receptor subfamily B member 1, also known as CLEC5B and NKR-P1A) is a type II transmembrane protein that is expressed on the majority of Natural Killer (NK) cells, NK T cells, and some T lymphocytes. CD161/KLRB1 is also expressed on Th17 cells, promotes their generation, and modulates their function. Engagement with its ligand lectin-like transcript 1 (LLT1) inhibits NK cell function, while LLT1 and CD161/KLRB1 interaction in the presence of a TCR signal enhances IFN-gamma production by T cells. There are several different CD161 isoforms in rodents and some function as activating receptors as well.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~18 kDa
• AA Sequence: QKSSIEKCSVDIQQSRNKTTERPGL LNCPIYWQQLREKCLLFSHTVNPWN NSLADCSTKESSLLLIRDKDELIHT QNLIRDKAILFWIGLNFSLSEKNWK WINGSFLNSNDLEIRGDAKENSCIS ISQTSVYSEYCSTEIRWICQKELTP VRNKVYPDS
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: KLRB1 killer cell lectin-like receptor subfamily B, member 1 [ Homo sapiens (human) ]
• Official Symbol: KLRB1
• Synonyms: KLRB1; killer cell lectin-like receptor subfamily B, member 1; NKR; killer cell lectin-like receptor subfamily B member 1; CD161; CLEC5B; hNKR P1A; NKR P1; NKR P1A; C-type lectin domain family 5 member B; natural killer cell surface protein P1A; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; MGC138614
• Gene ID: 3820
• mRNA Refseq: NM_002258
• Protein Refseq: NP_002249
• MIM: 602890
• UniProt ID: Q12918