Recombinant Human KLRB1 Protein, hIgG-His-tagged

• Cat.No.: KLRB1-228H
• Product Overview: Recombinant Human KLRB1(67-225aa) fused with hIgG-His tag at C-terminal was expressed in Insect cells.

Specification

• Description: KLRB1, also known as killer cell lectin-like receptor subfamily B member 1, is classified as a type II membrane protein because it has an external C terminus. It is expressed by NK cells and may be involved in the regulation of NK cell function. It plays a novel and important role in B cell maturation within the GC in humans. It is expressed by lymphocytes found in human gut and liver, as well as blood, especially natural killer (NK) cells, T helper 17 (Th17) cells, and a population of unconventional T cells known as mucosal-associated invariant T (MAIT) cells. It is also expressed, at intermediate levels, on a prominent subset of polyclonal CD8+ T cells, including antiviral populations that display a memory phenotype.
• Source: Insect cells
• Species: Human
• Tag: hIgG-His
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 45.7kDa (401aa) 40-57kDa (SDS-PAGE under reducing conditions)
• Protein length: 67-225aa
• AA Sequence: ADPQKSSIEK CSVDIQQSRN KTTERPGLLN CPIYWQQLRE KCLLFSHTVN PWNNSLADCS TKESSLLLIR DKDELIHTQN LIRDKAILFW
  IGLNFSLSEK NWKWINGSFL NSNDLEIRGD AKENSCISIS QTSVYSEYCS TEIRWICQKE LTPVRNKVYP DSLEPKSCDK THTCPPCPAP
  ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK
  VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV
  DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H
• Purity: > 90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml (determined by Absorbance at 280nm)

Gene Information

• Gene Name: KLRB1 killer cell lectin-like receptor subfamily B, member 1 [ Homo sapiens ]
• Official Symbol: KLRB1
• Synonyms: KLRB1; killer cell lectin-like receptor subfamily B, member 1; NKR; killer cell lectin-like receptor subfamily B member 1; CD161; CLEC5B; hNKR P1A; NKR P1; NKR P1A; C-type lectin domain family 5 member B; natural killer cell surface protein P1A; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; MGC138614
• Gene ID: 3820
• mRNA Refseq: NM_002258
• Protein Refseq: NP_002249
• MIM: 602890
• UniProt ID: Q12918