Recombinant Human KMT2B Protein, GST tagged

• Cat.No.: KMT2B-12H
• Product Overview: The peptide corresponding to amino acids 2551 - 2715 of the KMT2B (MLL4)-SET protein (accession number NP_055542.1) was expressed in E. coli. The peptide contains the SET domain of MLL4 that is responsible for methyltransferase activity. Recombinant KMT2B (MLL4)-SET contains an N-terminal GST-Tag with a molecular weight of 45.2 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2551-2715 aa
• Description: This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.
• Form: Supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100.
• Molecular Mass: 45.2 kDa
• Applications: Recombinant KMT2B (MLL4)-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
• Storage: Recombinant proteins in solution are temperature sensitive and must be stored at -80 centigrade to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Gene Information

• Gene Name: KMT2B lysine methyltransferase 2B [ Homo sapiens (human) ]
• Official Symbol: KMT2B
• Synonyms: KMT2B; lysine methyltransferase 2B; HRX2; MLL2; MLL4; TRX2; WBP7; DYT28; MLL1B; MRD68; WBP-7; CXXC10; histone-lysine N-methyltransferase 2B; W domain binding protein 7; histone-lysine N-methyltransferase MLL4; lysine (K)-specific methyltransferase 2B; mixed lineage leukemia gene homolog 2; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4; myeloid/lymphoid or mixed-lineage leukemia protein 4; trithorax homologue 2; EC 2.1.1.364
• Gene ID: 9757
• mRNA Refseq: NM_014727
• Protein Refseq: NP_055542
• MIM: 606834
• UniProt ID: Q9UMN6